Emergency Unit 061, Huesca, Spain.
Perpetuo Socorro, Primary Care Center, Huesca, Spain.
Pediatr Dermatol. 2020 Mar;37(2):294-300. doi: 10.1111/pde.14049. Epub 2020 Jan 29.
Previous studies have linked low serum vitamin D (VD) or 25-hydroxyvitamin D (25(OH)D) levels with increased severity of atopic dermatitis (AD) in children.
To investigate the association between serum VD (25(OH)D) levels and AD and AD severity, considering the influence of diet and sun exposure.
We performed a prospective cross-sectional study of healthy controls and children diagnosed with AD. Participants were recruited between January 2011 and December 2012, and the following parameters were assessed: age, sex, body mass index (BMI), AD severity, Fitzpatrick skin type, asthma and rhinitis history, dietary VD intake, daily potential sun-induced VD production, sunscreen use, 25(OH)D and IgE serum levels, and results of the ImmunoCAP Phadiatop Infant test.
The study population consisted of 105 healthy controls and 134 AD patients. Serum 25(OH)D levels were significantly lower in moderate and severe AD than in mild AD, although this association was only significant for patients with light Fitzpatrick skin type (mean(SD) 36.7 (11.9) ng/mL; moderate 28.8 [11.5] ng/mL; and severe 27.6 [12.1] ng/mL, P = .045). Logistic regression analysis revealed a positive association between severe AD and both positive ImmunoCAP Phadiatop test and BMI.
Our data support an association between VD deficiency and AD severity only in patients with light complexion.
先前的研究表明，血清维生素 D（VD）或 25-羟维生素 D（25（OH）D）水平较低与儿童特应性皮炎（AD）的严重程度增加有关。
探讨血清 VD（25（OH）D）水平与 AD 及 AD 严重程度的相关性，同时考虑饮食和阳光暴露的影响。
我们进行了一项健康对照者和 AD 患儿的前瞻性横断面研究。参与者于 2011 年 1 月至 2012 年 12 月间招募，评估以下参数：年龄、性别、体重指数（BMI）、AD 严重程度、Fitzpatrick 皮肤类型、哮喘和鼻炎病史、饮食 VD 摄入量、每日潜在阳光诱导 VD 生成量、防晒霜使用情况、25（OH）D 和 IgE 血清水平，以及 ImmunoCAP Phadiatop Infant 试验结果。
研究人群包括 105 名健康对照者和 134 名 AD 患者。中重度 AD 患者的血清 25（OH）D 水平明显低于轻度 AD 患者，但这种关联仅在皮肤颜色较浅的患者中具有统计学意义（平均（SD） 36.7（11.9）ng/mL；中度 28.8（11.5）ng/mL；重度 27.6（12.1）ng/mL，P=0.045）。Logistic 回归分析显示，严重 AD 与 ImmunoCAP Phadiatop 试验阳性和 BMI 均呈正相关。
我们的数据仅支持 VD 缺乏与浅色皮肤 AD 患者严重程度之间存在关联。
