Biochemistry Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Department of Dermatology, Andrology, Sexual Medicine and STDs, Faculty of Medicine, Helwan University, Cairo, Egypt.
J Dermatolog Treat. 2021 Mar;32(2):174-179. doi: 10.1080/09546634.2019.1643447. Epub 2019 Aug 2.
Vitamin D is a regulatory factor for immunity and skin barrier functions. It is hypothesized to be linked to atopic dermatitis (AD) which is characterized by interaction between epidermal barrier dysfunction and dysregulation of skin immune functions.
One hundred AD patients and one hundred and one normal controls were collected from outpatient clinic based on their clinical condition, both had measurement of 25-hydroxyvitamin D [25(OH)D]. We assessed the relationship between 25(OH)D deficiency and AD prevalence using adjusted Poisson regression model.
Serum 25(OH)D levels were significantly lower in cases than controls (mean 35.1 versus 22.6 ng/mL, < .001). The unadjusted prevalence ratios (PRs) (95% CI) for AD for comparing participants with intermediate and deficient vitamin D levels to those with optimal levels were 3.11 (1.91, 5.06) and 4.77 (2.99, 7.60), respectively. The association did not materially change after adjusting for potential confounders. In the fully adjusted analysis stratified by gender, PRs for AD for comparing male participants with intermediate and deficient vitamin D levels to those with optimal levels were 3.38 (1.21, 9.40) and 5.20 (1.91, 14.13), respectively, whereas in the female participants were 1.32 (0.96, 1.83) and 1.49 (1.04, 2.14), respectively (-interaction <.001).
In this case-control study in children, we found a statistically significant dose-response association between vitamin D deficiency and AD. We also observed a statistically significant effect modification of this association by gender. Further research is recommended to study this association longitudinally, and to examine whether treating vitamin D deficiency may potentially improve AD. Key points Can atopic dermatitis be associated with vitamin D deficiency? Serum 25(OH)D levels were significantly lower in cases with AD than in controls. Prevalence ratios for comparing male participants with intermediate and deficient vitamin D levels to those with optimal levels were 3.38 (1.21, 9.40) and 5.20 (1.91, 14.13), respectively, whereas in the female participants were 1.32 (0.96, 1.83) and 1.49 (1.04, 2.14), respectively (-interaction <.001). vitamin D deficiency is associated with AD in children, effect modification of this association by gender was also observed.
维生素 D 是免疫和皮肤屏障功能的调节因子。据推测，它与特应性皮炎（AD）有关，AD 的特征是表皮屏障功能障碍和皮肤免疫功能失调之间的相互作用。
根据临床情况，从门诊收集了 100 例 AD 患者和 101 例正常对照者，均进行了 25-羟维生素 D [25（OH）D]测量。我们使用调整后的泊松回归模型评估 25（OH）D 缺乏与 AD 患病率之间的关系。
病例组血清 25（OH）D 水平明显低于对照组（平均 35.1 与 22.6ng/mL，<.001）。对于比较维生素 D 中、低水平与最佳水平的参与者，AD 的未调整患病率比（PR）（95%CI）分别为 3.11（1.91，5.06）和 4.77（2.99，7.60）。在调整潜在混杂因素后，该关联没有实质性变化。在按性别分层的完全调整分析中，对于男性参与者，比较维生素 D 中、低水平与最佳水平的 AD 的 PR 分别为 3.38（1.21，9.40）和 5.20（1.91，14.13），而对于女性参与者，PR 分别为 1.32（0.96，1.83）和 1.49（1.04，2.14）（-交互作用<.001）。
在这项儿童病例对照研究中，我们发现维生素 D 缺乏与 AD 之间存在统计学上显著的剂量反应关联。我们还观察到这种关联存在性别效应修饰。建议进一步研究该关联的纵向研究，并研究治疗维生素 D 缺乏是否可能改善 AD。关键点 特应性皮炎是否与维生素 D 缺乏有关？ AD 患者的血清 25（OH）D 水平明显低于对照组。与最佳水平相比，比较男性参与者中、低维生素 D 水平与最佳水平的患病率比分别为 3.38（1.21，9.40）和 5.20（1.91，14.13），而女性参与者分别为 1.32（0.96，1.83）和 1.49（1.04，2.14）（-交互作用<.001）。 维生素 D 缺乏与儿童 AD 相关，且这种关联存在性别效应修饰。
