Dmochowski Marian, Gornowicz-Porowska Justyna, Bowszyc-Dmochowska Monika
Autoimmune Blistering Dermatoses Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, Poznan, Poland.
Postepy Dermatol Alergol. 2019 Dec;36(6):655-658. doi: 10.5114/ada.2019.91415. Epub 2019 Dec 30.
This mini-review presents an update on the direct immunofluorescence (DIF) for diagnosing dermatitis herpetiformis. The DIF of uninvolved, perilesional skin is a crucial laboratory procedure in diagnosing dermatitis herpetiformis (DH). IgA deposits at the dermal-epidermal junction (DEJ) of perilesional skin with DIF can also be found in coeliac patients with inflammatory skin diseases different from DH. In certain patients presenting with the rash resembling DH, the deposition of exclusively C3 at DEJ can be found. The term "granular C3 dermatosis" was proposed to name such a rash. Recent data on DH suggest that perhaps the very concept of DH that we are universally accepting now is misleading and should be revised.
本综述介绍了用于诊断疱疹样皮炎的直接免疫荧光法（DIF）的最新情况。对未受累的、皮损周围皮肤进行DIF检查是诊断疱疹样皮炎（DH）的一项关键实验室操作。在患有不同于DH的炎症性皮肤病的乳糜泻患者中，也可发现皮损周围皮肤的真皮表皮交界处（DEJ）有IgA沉积。在某些表现出类似DH皮疹的患者中，可发现仅在DEJ处有C3沉积。有人提出用“颗粒状C3皮肤病”这一术语来命名这种皮疹。关于DH的最新数据表明，或许我们目前普遍接受的DH这一概念具有误导性，应该予以修正。
