牙周健康与疾病中的中性粒细胞亚群：小型综述。
Neutrophil Subsets in Periodontal Health and Disease: A Mini Review.
机构信息
Department of Periodontology, Birmingham Dental School and Hospital, Birmingham, United Kingdom.
出版信息
Front Immunol. 2020 Jan 8;10:3001. doi: 10.3389/fimmu.2019.03001. eCollection 2019.
Abstract
Neutrophils are amongst the most abundant immune cells within the periodontal tissues and oral cavity. As innate immune cells, they are first line defenders at the tooth-mucosa interface, and can perform an array of different functions. With regard to these, it has been observed over many years that neutrophils are highly heterogeneous in their behavior. Therefore, it has been speculated that neutrophils, similarly to other leukocytes, exist in distinct subsets. Several studies have investigated different markers of neutrophils in oral health and disease in recent years in order to define potential cell subsets and their specific tasks. This research was inspired by recent advancements in other fields of medicine in this field. The aim of this review is to give an overview of the current evidence regarding the existence and presence of neutrophil subsets and their possible functions, specifically in the context of periodontitis, gingivitis, and periodontal health.
摘要
中性粒细胞是牙周组织和口腔中最丰富的免疫细胞之一。作为先天免疫细胞，它们是牙粘膜界面的第一道防线，能够执行多种不同的功能。多年来的研究观察到，中性粒细胞在行为上具有高度异质性。因此，人们推测中性粒细胞与其他白细胞一样，存在不同的亚群。近年来，为了确定潜在的细胞亚群及其特定功能，一些研究调查了口腔健康和疾病中中性粒细胞的不同标志物。这一研究受到了该领域其他医学领域的最新进展的启发。本综述的目的是概述目前关于中性粒细胞亚群的存在及其可能功能的证据，特别是在牙周炎、牙龈炎和牙周健康的背景下。
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