Xu Jia, Wen Chaoyu, Song Guangming, Lesaux Achraf Adib, Zhang Hao, Luo Yu
Department of Veterinary Medicine, Faculty of Agriculture, Jinhua University and Vocational Technology, Jinhua, China.
Haite Pet Nutrition & Health Institute, Hangzhou, China.
Front Microbiol. 2025 May 15;16:1561660. doi: 10.3389/fmicb.2025.1561660. eCollection 2025.
Rapid dietary transition in dogs can disturb the balance of gut microbiota, resulting in symptoms such as diarrhea and compromised immune function. Yeast probiotic (), has been shown to improve intestinal microbial composition and stimulate immune function. This study aims to investigate the effects of yeast probiotic supplementation on hematology, serum biochemistry, fecal IgA, microbiota, and metabolites in dogs undergoing rapid dietary transition.
Twenty healthy adult dogs were allocated into two groups: the control group (CON) and the yeast probiotic supplementation (YPS). All dogs were initially fed Diet 1 for 4 weeks, followed by an abrupt switch to Diet 2 for another 4 weeks. Throughout the study, the YPS group received 0.1% Actisaf Sc 50 product in a capsule given with their food, while the control group received a placebo.
Compared to the CON group, the YPS group exhibited lower serum globulin levels and higher albumin-to-globulin ratios on days 28 and 56 ( < 0.05). On day 56, the YPS group showed lower white blood cell counts and lower serum glucose levels ( < 0.05). Fecal IgA concentrations were higher in the YPS group on days 28, 30, 42, and 56 ( < 0.05). In the CON group, the abundance of Firmicutes significantly increased and the abundance of Fusobacteriota and Bacteroidota significantly decreased on days 42 compared to day 28 ( < 0.05). The YPS group showed a more stable gut microbiota transition post-dietary change. In the CON group, no significant changes in metabolite composition were observed 2 days after the dietary transition, but notable changes appeared after 2 weeks. In contrast, the YPS group exhibited substantial changes in metabolite composition 2 days after the diet change. Tyrosine metabolism showed significant changes in both groups of dogs following the dietary transition.
supplementation during rapid dietary transition in dogs led to beneficial changes in blood parameters, increased fecal IgA levels, and promoted a more stable gut microbiota. These findings suggest that yeast probiotics may support gut health and immune function during periods of dietary change.
犬类饮食的快速转变会扰乱肠道微生物群的平衡，导致腹泻和免疫功能受损等症状。酵母益生菌（）已被证明可以改善肠道微生物组成并刺激免疫功能。本研究旨在调查补充酵母益生菌对经历快速饮食转变的犬类血液学、血清生化、粪便免疫球蛋白A、微生物群和代谢产物的影响。
将20只健康成年犬分为两组：对照组（CON）和酵母益生菌补充组（YPS）。所有犬最初喂食饮食1持续4周，然后突然换成饮食2再持续4周。在整个研究过程中，YPS组在喂食时服用含0.1% Actisaf Sc 50产品的胶囊，而对照组服用安慰剂。
与CON组相比，YPS组在第28天和第56天时血清球蛋白水平较低，白蛋白与球蛋白比值较高（<0.05）。在第56天，YPS组白细胞计数较低，血清葡萄糖水平较低（<0.05）。在第28天、第30天、第42天和第56天，YPS组粪便免疫球蛋白A浓度较高（<0.05）。与第28天相比，CON组在第42天时厚壁菌门丰度显著增加，梭杆菌门和拟杆菌门丰度显著降低（<0.05）。YPS组在饮食变化后肠道微生物群过渡更稳定。在CON组中，饮食转变后2天代谢物组成未观察到显著变化，但2周后出现明显变化。相比之下，YPS组在饮食改变后2天代谢物组成出现显著变化。饮食转变后两组犬的酪氨酸代谢均出现显著变化。
在犬类快速饮食转变期间补充酵母益生菌可使血液参数发生有益变化，增加粪便免疫球蛋白A水平，并促进更稳定的肠道微生物群。这些发现表明酵母益生菌可能在饮食变化期间支持肠道健康和免疫功能。
