Cardiology Department, Mitera General Hospital, Hygeia Group, Athens, Greece.
Center of Basic Research, Biomedical Research Foundation Academy of Athens, Greece.
Europace. 2020 Mar 1;22(3):342-351. doi: 10.1093/europace/euaa009.
Atrial fibrillation (AF), the most commonly diagnosed arrhythmia, affects a notable percentage of the population and constitutes a major risk factor for thromboembolic events and other heart-related conditions. Fibrosis plays an important role in the onset and perpetuation of AF through structural and electrical remodelling processes. Multiple molecular pathways are involved in atrial substrate modification and the subsequent maintenance of AF. In this review, we aim to recapitulate underlying molecular pathways leading to atrial fibrosis and to indicate existing gaps in the complex interplay of atrial fibrosis and AF.
心房颤动（AF）是最常见的心律失常，影响着相当大比例的人群，是血栓栓塞事件和其他与心脏相关疾病的主要危险因素。纤维化通过结构和电重构过程在 AF 的发生和持续中起着重要作用。多种分子途径参与了心房基质的修饰和随后的 AF 的维持。在这篇综述中，我们旨在概述导致心房纤维化的潜在分子途径，并指出心房纤维化和 AF 复杂相互作用中存在的差距。
