Metabolic Unit, Research Centre on Aging, CIUSSS de l'Estrie-CHUS, Québec, Canada.
Faculty of Physical Activity Sciences, University of Sherbrooke, Québec, Canada.
J Cachexia Sarcopenia Muscle. 2020 Apr;11(2):343-347. doi: 10.1002/jcsm.12520. Epub 2020 Jan 30.
Fat-free mass (FFM) has long been recognized to play a role in metabolic homeostasis. Over the years, it has become widely accepted by the scientific and general community alike that having a greater FFM can be protective for metabolic health. Hence, in the context of an aging population concurrently facing sarcopenia and an elevated incidence of metabolic diseases, substantial efforts are being made to study and develop interventions aiming to maintain or increase FFM. However, accumulating evidence now suggests that a large FFM may be deleterious to metabolic health, at least in some populations. The objective of this article is thus to raise awareness surrounding these results and to explore possible explanations and mechanisms underlying this counterintuitive association.
去脂体重（FFM）长期以来一直被认为在代谢稳态中发挥作用。多年来，科学界和普通大众都普遍接受了这样一种观点，即拥有更大的 FFM 可以对代谢健康起到保护作用。因此，在人口老龄化的背景下，同时面临肌肉减少症和代谢性疾病发病率升高的问题，人们正在努力研究和开发旨在维持或增加 FFM 的干预措施。然而，越来越多的证据表明，大量的 FFM 可能对代谢健康有害，至少在某些人群中是如此。因此，本文的目的是提高对这些结果的认识，并探讨这种反直觉关联背后可能的解释和机制。
