铁光催化实现分子内芳香 C-H 酰氧基化反应。
Intramolecular Aromatic C-H Acyloxylation Enabled by Iron Photocatalysis.
机构信息
Center for Supramolecular Chemistry and Catalysis and Department of Chemistry, College of Sciences , Shanghai University , 99 Shangda Road , Shanghai 200444 , China.
CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences , Chinese Academy of Sciences , 345 Lingling Road , Shanghai 20032 , China.
出版信息
Org Lett. 2020 Feb 21;22(4):1385-1389. doi: 10.1021/acs.orglett.0c00002. Epub 2020 Jan 30.
A mild and efficient protocol for the intramolecular aromatic C-H oxygenation of 2-biphenylcarboxylic acids has been achieved via iron photocatalysis. The 2-biphenylcarboxylic acids with a diverse array of substituents at both phenyl rings could furnish the oxygenation products in good to excellent yields. We speculate that the aryl carboxylate-iron(III) complexes should generate the aroyloxy radicals and iron(II) upon visible light irradiation.
通过铁光催化实现了温和高效的 2-联苯羧酸分子内芳香 C-H 氧化反应。具有不同取代基的 2-联苯羧酸在两个苯环上都能以良好到优异的收率得到氧化产物。我们推测在可见光照射下，芳基羧酸盐-铁（III）配合物应该生成酰氧基自由基和铁（II）。
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