Li Juan, Wu Yujing, Zhang Dongyang, Nie Jing
Medicine (Baltimore). 2020 Jan;99(5):e18492. doi: 10.1097/MD.0000000000018492.
There are differences among the outcomes regarding cognitive impairment in heart failure (HF) because the evidence is fragmented and sample size is small. Therefore we aimed to systematically review and analyze the available evidence about the association between HF and dementia.
In the present study, we searched for articles published until August 2019 in the following databases: PubMed, Web of Science, EMBASE, Medline and Google Scholar. The pooled multivariate odds ratio (OR) or relative risk (RR) and 95% confidence intervals (CI) were obtained by the use of STATA 12.0 software.
The meta-analysis showed a positive association between HF and risk of all-cause dementia (OR/RR = 1.28, 95% CI 1.15 to 1.43, I = 70.0%, P < 0.001). Additionally, the study showed no significant association between HF and risk of Alzheimer's disease (AD) (OR/RR = 1.38, 95% CI 0.90 to 2.13, I = 74.8%, P = 0.008).
In conclusion, HF was associated with an increased risk of developing dementia. In addition, large scale prospective studies are essential to explore the associations between HF and risk of AD.
由于证据零散且样本量小，心力衰竭（HF）患者认知障碍的结局存在差异。因此，我们旨在系统回顾和分析关于HF与痴呆症之间关联的现有证据。
在本研究中，我们检索了截至2019年8月在以下数据库中发表的文章：PubMed、科学网、EMBASE、Medline和谷歌学术。使用STATA 12.0软件获得合并的多变量优势比（OR）或相对风险（RR）以及95%置信区间（CI）。
荟萃分析显示HF与全因痴呆风险之间存在正相关（OR/RR = 1.28，95% CI 1.15至1.43，I = 70.0%，P < 0.001）。此外，该研究显示HF与阿尔茨海默病（AD）风险之间无显著关联（OR/RR = 1.38，95% CI 0.90至2.13，I = 74.8%，P = 0.008）。
总之，HF与患痴呆症风险增加有关。此外，大规模前瞻性研究对于探索HF与AD风险之间的关联至关重要。
