School of Medicine, Nankai University, Tianjin, 300071, China.
Department of Neurology, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, Beijing, 100853, China.
J Headache Pain. 2018 Oct 11;19(1):95. doi: 10.1186/s10194-018-0925-4.
Until now, headache disorders have not been established as a risk factor for dementia. The aim of this study was to determine whether headache was associated with an increased risk of dementia.
We systematically searched electronic databases, including PubMed, Embase, and Web of Science, for studies investigating the association between headache and dementia. We then conducted a meta-analysis to determine a pooled-effect estimate of the association.
We identified 6 studies (covering 291,549 individuals) to investigate the association between headache and the risk of all-cause dementia or Alzheimer's disease (AD). Pooled analyses showed that any headache was associated with a 24% greater risk of all-cause dementia (relative risk [RR] = 1.24; 95% confidential interval [CI]: 1.09-1.41; P = 0.001), and that any headache was not statistically significantly associated with an increased risk of AD (RR = 1.47; 95% CI: 0.82-2.63; P = 0.192).
Our results indicated that any headache was associated with an increased risk of all-cause dementia. However, additional studies are warranted to further confirm and understand the association.
迄今为止，头痛疾病尚未被确定为痴呆的风险因素。本研究旨在确定头痛是否与痴呆风险增加有关。
我们系统地检索了电子数据库，包括 PubMed、Embase 和 Web of Science，以调查头痛与痴呆之间的关联。然后，我们进行了荟萃分析，以确定头痛与痴呆风险之间关联的汇总效应估计值。
我们确定了 6 项研究（涵盖 291549 人）来调查头痛与全因痴呆或阿尔茨海默病（AD）风险之间的关联。汇总分析表明，任何头痛都与全因痴呆的风险增加 24%相关（相对风险 [RR] = 1.24；95%置信区间 [CI]：1.09-1.41；P = 0.001），而任何头痛与 AD 的风险增加无统计学显著相关性（RR = 1.47；95% CI：0.82-2.63；P = 0.214）。
我们的结果表明，任何头痛都与全因痴呆的风险增加相关。然而，需要进一步的研究来进一步证实和理解这种关联。
