多囊卵巢综合征女性排卵功能障碍的生活方式和环境因素贡献。
Lifestyle and environmental contributions to ovulatory dysfunction in women of polycystic ovary syndrome.
机构信息
Center for Reproductive Medicine, Shandong University, No.157 of Jingliu Street, Jinan, 250012, Shandong, China.
National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, No.44 of Wenhua Street, Jinan, 250012, Shandong, China.
出版信息
BMC Endocr Disord. 2020 Jan 30;20(1):19. doi: 10.1186/s12902-020-0497-6.
BACKGROUND
Polycystic ovary syndrome (PCOS) is the most common reason of anovulatory infertility. Environmental factor is one of the main causes of PCOS, but its contribution to ovulatory dysfunction in PCOS remains unknown.
METHODS
A total of 2217 infertile women diagnosed as PCOS according to Rotterdam criteria were recruited, including 1979 women with oligo-anovulation (OA group) and 238 women with normal -anovulation (non OA group). Besides, 279 healthy control women of reproductive age were enrolled as controls.
RESULTS
Frequencies of snoring (PCOS-OA group, PCOS-non-OA group, control group: 29.30% vs 18.10% vs 11.50%, P < 0.01), smoking (37.70% vs 28.10% vs 12.20%, P < 0.01), plastic tableware usage (38.30% vs 28.10% vs 25.40%, P < 0.01) and indoor decoration (32.10% vs 24.80% vs 16.80%, P < 0.01) were highest in PCOS-OA group. After adjusted for multivariable, difference remained significant between PCOS-OA group and the other two groups. PCOS-OA women preferred a meat favorable diet compared to PCOS-non-OA group (54.60% vs 41.30%, P < 0.01). There was no difference between three groups in exercise, frequency of insomnia, and alcohol consumption.
CONCLUSIONS
Smoking, snoring, hyper-caloric diet, plastic tableware usage and indoor decoration were found to be associated with an increased risk for ovulatory dysfunction in women suffering from PCOS.
背景
多囊卵巢综合征（PCOS）是无排卵性不孕的最常见原因。环境因素是 PCOS 的主要原因之一，但它对 PCOS 排卵功能障碍的贡献尚不清楚。
方法
共纳入 2217 名符合 Rotterdam 标准诊断为 PCOS 的不孕妇女，其中 1979 名排卵障碍（OA 组），238 名排卵正常（非 OA 组）。此外，还纳入了 279 名生育期健康对照妇女作为对照组。
结果
鼾症（PCOS-OA 组、PCOS-non-OA 组、对照组：29.30% vs 18.10% vs 11.50%，P<0.01）、吸烟（37.70% vs 28.10% vs 12.20%，P<0.01）、使用塑料餐具（38.30% vs 28.10% vs 25.40%，P<0.01）和室内装修（32.10% vs 24.80% vs 16.80%，P<0.01）的频率在 PCOS-OA 组最高。校正多变量后，PCOS-OA 组与其他两组仍有差异。与 PCOS-non-OA 组相比，PCOS-OA 组的女性更喜欢肉类偏好的饮食（54.60% vs 41.30%，P<0.01）。三组在运动、失眠频率和饮酒方面无差异。
结论
吸烟、打鼾、高卡路里饮食、使用塑料餐具和室内装修与 PCOS 女性排卵功能障碍风险增加有关。
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