棉兰地区结直肠癌分化程度及肿瘤位置的癌胚抗原水平比较
Comparison of Carcinoembryonic Antigen Levels Among Degree of Differentiation and Colorectal Cancer's Location in Medan.
作者信息
Siregar Gontar Alamsyah, Sibarani Henry
机构信息
Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
出版信息
Open Access Maced J Med Sci. 2019 Oct 14;7(20):3447-3450. doi: 10.3889/oamjms.2019.442. eCollection 2019 Oct 30.
BACKGROUND
The most widely used tumour markers, especially in colorectal malignancy, is Carcinoembryonic antigen (CEA).
AIM
This study was aimed to investigate CEA value among the degree of differentiation and tumour location.
METHODS
A cross-sectional analytical study was used in this study on eighty consecutive patients with colorectal carcinoma (CRC) at Adam Malik General Hospital and Permata Bunda Hospital, Medan, Indonesia. All data were analysed using SPSS for Windows version 21.
RESULTS
They were rectal cancer 49.4%, left-sided colon cancer 43.2% and right-sided colon cancer 6.2%. Histopathology findings were well-differentiated 40.7%, moderate differentiated 32.1% and poorly differentiated 25.9%. There were no correlations between CEA level and haemoglobin level, white blood cells count, and platelet count. There was no significant difference between CEA and location of the tumour (p = 0.70), although CEA level was significantly differenced among histopathology findings (p = 0.03). CEA levels were and associated with the degree of differentiation.
CONCLUSION
CEA levels increased in well-differentiated colorectal carcinoma especially in rectal cancer.
背景
最广泛使用的肿瘤标志物，尤其是在结直肠癌中，是癌胚抗原（CEA）。
目的
本研究旨在探讨不同分化程度和肿瘤位置的癌胚抗原值。
方法
本研究采用横断面分析研究，对印度尼西亚棉兰市亚当·马利克综合医院和Permata Bunda医院连续80例结直肠癌（CRC）患者进行研究。所有数据均使用SPSS for Windows 21版进行分析。
结果
直肠癌占49.4%，左侧结肠癌占43.2%，右侧结肠癌占6.2%。组织病理学结果显示高分化占40.7%，中分化占32.1%，低分化占25.9%。癌胚抗原水平与血红蛋白水平、白细胞计数和血小板计数之间无相关性。癌胚抗原与肿瘤位置之间无显著差异（p = 0.70），尽管癌胚抗原水平在组织病理学结果之间存在显著差异（p = 0.03）。癌胚抗原水平与分化程度相关。
结论
高分化结直肠癌尤其是直肠癌中癌胚抗原水平升高。
Zotero 插件