Greenlee Joshua D, King Michael R
Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA.
Biomicrofluidics. 2020 Jan 28;14(1):011502. doi: 10.1063/1.5133970. eCollection 2020 Jan.
The majority of all cancers metastasize initially through the lymphatic system. Despite this, the mechanisms of lymphogenous metastasis remain poorly understood and understudied compared to hematogenous metastasis. Over the past few decades, microfluidic devices have been used to model pathophysiological processes and drug interactions in numerous contexts. These devices carry many advantages over traditional 2D systems, allowing for better replication of microenvironments. This review highlights prominent fluidic devices used to model the stages of cancer metastasis via the lymphatic system, specifically within lymphangiogenesis, vessel permeability, tumor cell chemotaxis, transendothelial migration, lymphatic circulation, and micrometastases within the lymph nodes. In addition, we present perspectives for the future roles that microfluidics might play within these settings and beyond.
大多数癌症最初是通过淋巴系统转移的。尽管如此，与血行转移相比，淋巴转移的机制仍知之甚少且研究不足。在过去几十年中，微流控装置已被用于在多种情况下模拟病理生理过程和药物相互作用。这些装置比传统的二维系统具有许多优势，能够更好地复制微环境。本综述重点介绍了用于模拟癌症通过淋巴系统转移阶段的重要微流控装置，特别是在淋巴管生成、血管通透性、肿瘤细胞趋化性、跨内皮迁移、淋巴循环以及淋巴结内的微转移等方面。此外，我们还展望了微流控技术在这些领域及其他领域未来可能发挥的作用。
