Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Preclinical Imaging Center PRIME, Nijmegen, The Netherlands.
Obes Rev. 2020 Jun;21(6):e13005. doi: 10.1111/obr.13005. Epub 2020 Jan 30.
In this review, we discuss the role of adipokines in the onset of puberty in children with obesity during adrenarche and gonadarche and provide a clear and detailed overview of the biological processes of two major players, leptin and adiponectin. Adipokines, especially leptin and adiponectin, seem to induce an early onset of puberty in girls and boys with obesity by affecting the hypothalamic-pituitary-gonadal (HPG) axis. Moreover, adipokines and their receptors are expressed in the gonads, suggesting a role in sexual maturation and reproduction. All in all, adipokines may be a clue in understanding mechanisms underlying the onset of puberty in childhood obesity and puberty onset variability.
在这篇综述中，我们讨论了脂肪因子在肾上腺皮质功能初现和性腺功能初现期间肥胖儿童青春期启动中的作用，并对两个主要参与者瘦素和脂联素的生物学过程进行了清晰详细的概述。脂肪因子，尤其是瘦素和脂联素，似乎通过影响下丘脑-垂体-性腺（HPG）轴，导致肥胖的女孩和男孩青春期提前。此外，脂肪因子及其受体在性腺中表达，表明它们在性成熟和生殖中发挥作用。总之，脂肪因子可能是理解儿童肥胖青春期启动和青春期启动变异性机制的线索。
