Université Paris Saclay, CEA, INSERM, CNRS, BioMaps, Service Hospitalier Frédéric Joliot, Bertrand KUHNAST, 4 place du général Leclerc, 91401 Orsay, France.
Chem Commun (Camb). 2020 Feb 25;56(16):2507-2510. doi: 10.1039/c9cc09434b.
Radiolabeling of peptides with fluorine-18 is hurdled by their chemical sensitivity and complicated processes. Original triflyl-pyridine intermediates afforded ammonium precursors that were radiolabeled at low temperature. From that study, a generic tag has been designed to allow a simple one-step/late-stage radiolabelling of peptides. The strategy has been transposed to an automated "on-resin" radiolabelling.
放射性标记氟-18 的肽受到其化学敏感性和复杂过程的阻碍。原始的三氟吡啶中间体提供了铵前体，可以在低温下进行放射性标记。从该研究中，设计了一种通用标记物，以允许肽的简单一步/后期放射性标记。该策略已被转换为自动化的“在树脂上”放射性标记。
