School of Public Health, University of California, Berkeley, California 94720, USA; email:
Annu Rev Food Sci Technol. 2020 Mar 25;11:275-294. doi: 10.1146/annurev-food-032519-051618. Epub 2020 Jan 31.
In general, foodborne diseases present themselves with gastrointestinal symptoms caused by bacterial, viral, and parasitic pathogens well established to be foodborne. These pathogens are also associated with extraintestinal clinical manifestations. Recent studies have suggested that and , which both cause common extraintestinal infections such as urinary tract and bloodstream infections, may also be foodborne. The resolution and separation of these organisms into pathotypes versus commensals by modern genotyping methods have led to the identification of key lineages of these organisms causing outbreaks of extraintestinal infections. These epidemiologic observations suggested common- or point-source exposures, such as contaminated food. Here, we describe the spectrum of extraintestinal illnesses caused by recognized enteric pathogens and then review studies that demonstrate the potential role of extraintestinal pathogenic (ExPEC) and as foodborne pathogens. The impact of global food production and distribution systems on the possible foodborne spread of these pathogens is discussed.
一般来说，食源性疾病表现为胃肠道症状，由已被证实为食源性的细菌、病毒和寄生虫病原体引起。这些病原体也与肠道外的临床表现有关。最近的研究表明， 和 ，它们都会引起常见的肠道外感染，如尿路感染和血流感染，也可能是食源性的。通过现代基因分型方法将这些生物体分为病原体和共生体，导致了引起肠道外感染爆发的这些生物体的关键谱系的鉴定。这些流行病学观察表明，存在共同或单点暴露源，如污染食物。在这里，我们描述了由公认的肠道病原体引起的肠道外疾病谱，然后回顾了一些研究，这些研究表明肠道外致病性大肠杆菌 (ExPEC) 和 可能是食源性病原体。讨论了全球食品生产和分销系统对这些病原体可能的食源性传播的影响。
