Competition, Addiction and Social Neuroscience Lab, Department of Psychology, School of Social and Behavioral Sciences, Nanjing University, Nanjing, China; Institute for Brain Sciences, Nanjing University, Nanjing, China.
Vulnerability of Psychiatric and Addictive Disorders, Institute of Psychiatry and Neuroscience of Paris, INSERM UMRS1266, Paris, France.
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jun 8;100:109880. doi: 10.1016/j.pnpbp.2020.109880. Epub 2020 Jan 28.
The endocrine system plays an essential role in communication between various organs of the body to maintain homeostasis. Both substance use disorders (SUDs) and non-substance abuse disrupt this system and lead to hormonal dysregulations. Here, we focus on the comparison between the function of the endocrine system in gambling disorders and alcohol addiction to understand the commonalities and differences in their neurobiological and psychological underpinnings. We review human research to compare findings on gambling addiction and alcohol dependence pertaining to the dynamic interplay between testosterone and cortisol. Understanding and classifying similarities in hormonal responses between behavioural addiction and SUDs may facilitate development of treatments and therapeutic interventions across different types of addictive disorders, while describing differences may shed light on therapeutic interventions for specific disorders. Although research on gambling addiction is in its infancy, such evaluation may still have a positive effect for addiction research, thereby stimulating discovery of "crossover" pharmacotherapies with benefits for both SUDs and nonsubstance addictions.
内分泌系统在身体各器官之间的通讯中起着至关重要的作用，以维持体内平衡。物质使用障碍（SUDs）和非物质滥用都会破坏这个系统，并导致激素失调。在这里，我们专注于比较赌博障碍和酒精成瘾中内分泌系统的功能，以了解它们在神经生物学和心理学基础方面的异同。我们回顾了人类的研究，比较了与睾酮和皮质醇之间动态相互作用有关的赌博成瘾和酒精依赖的发现。理解和分类行为成瘾和 SUDs 之间激素反应的相似性可能有助于开发针对不同类型成瘾障碍的治疗和治疗干预措施，而描述差异可能有助于针对特定障碍的治疗干预措施。尽管赌博成瘾的研究还处于起步阶段，但这种评估可能对成瘾研究仍有积极影响，从而刺激发现对 SUDs 和非物质成瘾都有好处的“交叉”药物治疗方法。
