Centers for Disease Control and Prevention (CDC), National Center for Environmental Health (NCEH), Division of Laboratory Sciences (DLS), 4770 Buford Hwy NE, Atlanta, GA, 30341, USA.
Queensland Alliance for Environmental Health Science (QAEHS), The University of Queensland, 20 Cornwall Street Woolloongabba, 4102, Queensland, Australia.
Chemosphere. 2020 Jun;248:125905. doi: 10.1016/j.chemosphere.2020.125905. Epub 2020 Jan 13.
The objective of the study was to determine the human serum elimination half-life of polybrominated diphenyl ethers (PBDEs) adjusted for ongoing exposure in subjects moving from a higher exposure region (North America) to a lower exposure region (Australia). The study population was comprised of exchange students and long-term visitors from North America moving to Brisbane, Australia (N = 27) and local residents (N = 23) who were followed by repeated serum sampling every other month. The local residents were sampled to adjust for ongoing exposure in Australia. Only one visitor remained in Australia for a period of time similar to the elimination half-life and had a sufficiently high initial concentration of PBDEs to derive a half-life. This visitor arrived in Australia in March of 2011 and remained in the country for 1.5 years. Since the magnitude of PBDE exposure is lower in Australia than in North America we observed an apparent 1st order elimination curve over time from which we have estimated the serum elimination half-lives for BDE28, BDE47, BDE99, BDE100, and BDE153 to be 0.942, 1.19, 1.03, 2.16, and 4.12 years, respectively. Uncertainty in the estimates were estimated using a Monte Carlo simulation. The human serum elimination half-life adjusted for ongoing exposure can allow us to assess the effectiveness and reduction in exposure in the general population following phase out of commercial penta- and octaBDE in 2004 in the United States.
本研究旨在确定从高暴露地区（北美）转移到低暴露地区（澳大利亚）的人群中，持续暴露调整后的多溴二苯醚（PBDEs）的人体血清消除半衰期。研究人群包括从北美到澳大利亚布里斯班的交换生和长期访客（N=27）以及当地居民（N=23），他们每隔一个月接受一次重复的血清采样。对当地居民进行采样以调整澳大利亚的持续暴露。只有一名访客在与消除半衰期相似的时间内在澳大利亚停留，并具有足够高的初始 PBDEs 浓度以得出半衰期。这位访客于 2011 年 3 月抵达澳大利亚，并在该国停留了 1.5 年。由于澳大利亚的 PBDE 暴露程度低于北美，因此我们观察到随着时间的推移，明显呈现出 1 阶消除曲线，从中我们估计 BDE28、BDE47、BDE99、BDE100 和 BDE153 的血清消除半衰期分别为 0.942、1.19、1.03、2.16 和 4.12 年。使用蒙特卡罗模拟估计了估计值的不确定性。调整后的人体血清消除半衰期可以使我们在美国于 2004 年淘汰商用五溴和八溴二苯醚后，评估普通人群中暴露的有效性和减少程度。
