School of Public Health and Social Work and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia; The University of Queensland, Queensland Alliance for Environmental Sciences, Australia.
Centers for Disease Control and Prevention, Atlanta, USA; The University of Queensland, Queensland Alliance for Environmental Sciences, Australia.
Environ Int. 2018 Dec;121(Pt 1):357-364. doi: 10.1016/j.envint.2018.09.014. Epub 2018 Sep 20.
In Australia, systematic biomonitoring of persistent organic pollutants (POPs) in pooled serum samples stratified by age and sex has occurred every two years between 2002/03 and 2012/13. Multiple regression modeling on log10-transformed serum pool concentrations of BDEs 47, 99, 100 and 153 and on the sum of these (ΣPBDE) was conducted to examine trends by sex and time since baseline, stratified by age group. Temporal trends were age- and congener-specific, with the largest changes per year of observation in the 0-4 year old group, with β (SE) = -0.098 (0.013) for logBDE47; -0.119 (0.012) for logBDE99; -0.084 (0.014) for logBDE100, and -0.053 (0.013) for logBDE153, all p < 0.001. Adults over age 16 showed much smaller decreasing temporal trends for BDE47 and BDE99, no significant changes in BDE100, and, for the oldest age groups, slight increases in BDE153. As a result, ΣPBDE concentrations were stable over the entire time period in adults older than 16. Concentrations of each BDE in pools from females aged 31-60 were significantly lower compared to males. Relative proportions of BDE47 declined, while BDE153 accounted for a greater share of ΣPBDE over time. Whereas previously we saw a large elevation in the youngest age groups compared to older children and adults, this is no longer the case. This may be due to a decline in infant and toddler exposures in the indoor environment as use of PBDEs in consumer products has been phased out, suggesting temporal changes in the relative sources of exposure for young children in Australia.
在澳大利亚，2002/03 年至 2012/13 年期间，每两年对按年龄和性别分层的 pooled 血清样本中的持久性有机污染物（POPs）进行系统的生物监测。对 BDEs 47、99、100 和 153 的血清池浓度进行对数转换，并对这些浓度进行求和（ΣPBDE），采用多元回归模型，对性别和自基线以来的时间进行分析，按年龄组分层。趋势分析结果显示，时间和同系物特异性，观察到的每年变化最大的是 0-4 岁组，logBDE47 的β（SE）= -0.098（0.013）；logBDE99 的β（SE）= -0.119（0.012）；logBDE100 的β（SE）= -0.084（0.014）；logBDE153 的β（SE）= -0.053（0.013），所有 p 值均<0.001。16 岁以上的成年人 BDE47 和 BDE99 的时间趋势呈明显下降，BDE100 没有明显变化，对于最年长的年龄组，BDE153 略有增加。因此，16 岁以上成年人的ΣPBDE 浓度在整个时期内保持稳定。31-60 岁女性血清池中的每种 BDE 浓度均显著低于男性。BDE47 的相对比例下降，而 BDE153 在 ΣPBDE 中的比例随着时间的推移而增加。虽然之前我们看到最年轻的年龄组与较大的儿童和成年人相比有很大的升高，但现在已经不是这样了。这可能是由于室内环境中婴儿和学步儿童的接触减少所致，因为消费产品中多溴二苯醚的使用已逐步淘汰，这表明澳大利亚幼儿接触的相对来源发生了时间变化。
