Markitziu A, Shani J, Avni J
Department of Oral Diagnosis, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.
Oral Surg Oral Med Oral Pathol. 1988 Nov;66(5):551-7. doi: 10.1016/0030-4220(88)90374-x.
Salivary gland function was studied in 14 manic-depressive patients treated with lithium carbonate (Li) for 4 to 120 months. Function level was evaluated by means of sialometry, dynamic salivary scintigraphy, and sialography. Daily Li dose, serum Li concentration, duration of Li therapy, and caries activity index were correlated with the salivary function parameters studied. Hyposalivation was noted in 71% of the patients, showing good correlation with the scintigraphic (r = 0.94) and sialographic (r = 0.87) results. Duration of Li therapy was poorly correlated with the degree of salivary gland dysfunction and with the caries activity index, whereas the correlation between duration of therapy and each of the three salivary function parameters was erratic. Because four of the patients exhibited normal salivation, we suggest that there are some additional factors (e.g., genetic or thyroid function level) that might be involved in salivary dysfunction connected with Li therapy.
对14例接受碳酸锂（Li）治疗4至120个月的躁郁症患者的唾液腺功能进行了研究。通过唾液流量测定、动态唾液闪烁显像和唾液造影评估功能水平。每日Li剂量、血清Li浓度、Li治疗持续时间和龋齿活动指数与所研究的唾液功能参数相关。71%的患者出现唾液分泌减少，与闪烁显像结果（r = 0.94）和唾液造影结果（r = 0.87）显示出良好的相关性。Li治疗持续时间与唾液腺功能障碍程度和龋齿活动指数的相关性较差，而治疗持续时间与三个唾液功能参数中每一个的相关性不稳定。由于4例患者唾液分泌正常，我们认为存在一些其他因素（如遗传或甲状腺功能水平）可能与Li治疗相关的唾液功能障碍有关。
