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[ Brugada综合征:心脏性猝死的风险分层与预防 ]

[Brugada syndrome : Risk stratification and prevention of sudden cardiac death].

作者信息

Eckardt Lars

机构信息

Klinik für Kardiologie II - Rhythmologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Deutschland.

出版信息

Herzschrittmacherther Elektrophysiol. 2020 Mar;31(1):39-47. doi: 10.1007/s00399-020-00667-x. Epub 2020 Jan 31.

DOI:10.1007/s00399-020-00667-x
PMID:32006164
Abstract

Brugada syndrome is ion channelopathy defined by coved type ST-elevation in at least one right precordial ECG lead. Patients may suffer from ventricular tachycardia/fibrillation, which may cause syncope or sudden cardiac death. The majority of patients are likely to remain asymptomatic throughout life. A correct ECG diagnosis remains challenging. The implantable cardioverter/defibrillator (ICD) is the only established therapy to protect against sudden cardiac death. Thus, individual risk stratification is of major clinical relevance in primary prevention. The present article gives an update on current risk stratification and novel therapeutic options apart from ICD therapy.

摘要

Brugada综合征是一种离子通道病,其定义为至少一个右胸前心电图导联出现穹窿型ST段抬高。患者可能会发生室性心动过速/心室颤动,这可能导致晕厥或心源性猝死。大多数患者可能终生无症状。正确的心电图诊断仍然具有挑战性。植入式心脏复律除颤器(ICD)是预防心源性猝死的唯一既定疗法。因此,个体风险分层在一级预防中具有重要的临床意义。本文介绍了当前风险分层以及除ICD治疗之外的新型治疗选择的最新情况。

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本文引用的文献

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Implantable cardioverter defibrillators in patients with electrical heart disease and hypertrophic cardiomyopathy: data from the German device registry.植入式心脏转复除颤器在电性心脏病和肥厚型心肌病患者中的应用:来自德国器械注册登记研究的数据。
Clin Res Cardiol. 2020 Apr;109(4):508-512. doi: 10.1007/s00392-019-01532-9. Epub 2019 Jul 31.
2
Spotlight on S-ICD™ therapy: 10 years of clinical experience and innovation.聚焦 S-ICD™ 治疗:十年临床经验与创新。
Europace. 2019 Jul 1;21(7):1001-1012. doi: 10.1093/europace/euz029.
3
Present Status of Brugada Syndrome: JACC State-of-the-Art Review.
Brugada 综合征的现状:美国心脏病学会的最新综述
J Am Coll Cardiol. 2018 Aug 28;72(9):1046-1059. doi: 10.1016/j.jacc.2018.06.037.
4
Assessing the Malignant Ventricular Arrhythmic Substrate in Patients With Brugada Syndrome.评估 Brugada 综合征患者的恶性室性心律失常基质。
J Am Coll Cardiol. 2018 Apr 17;71(15):1631-1646. doi: 10.1016/j.jacc.2018.02.022.
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Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome.135例Brugada综合征患者的电基质消除
Circ Arrhythm Electrophysiol. 2017 May;10(5):e005053. doi: 10.1161/CIRCEP.117.005053.
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Heart Rhythm. 2017 Aug;14(8):1147-1154. doi: 10.1016/j.hrthm.2017.04.019. Epub 2017 Apr 12.
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Eur Heart J. 2017 Jun 7;38(22):1756-1763. doi: 10.1093/eurheartj/ehx119.
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[Indications for implantable loop recorders in patients with channelopathies and ventricular tachycardias].[离子通道病和室性心动过速患者植入式环形记录仪的适应证]
Herzschrittmacherther Elektrophysiol. 2016 Dec;27(4):360-365. doi: 10.1007/s00399-016-0474-y.
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Cardiol Young. 2016 Aug;26(6):1044-55. doi: 10.1017/S1047951116000548. Epub 2016 May 6.
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