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钕在电子显微镜中作为铀的替代对比剂。

Neodymium as an alternative contrast for uranium in electron microscopy.

机构信息

Department of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

出版信息

Histochem Cell Biol. 2020 Apr;153(4):271-277. doi: 10.1007/s00418-020-01846-0. Epub 2020 Feb 1.

DOI:10.1007/s00418-020-01846-0
PMID:32008069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7160090/
Abstract

Uranyl acetate is the standard contrasting agent in electron microscopy (EM), but it is toxic and radioactive. We reasoned neodymium acetate might substitute uranyl acetate as a contrasting agent, and we find that neodymium acetate indeed can replace uranyl acetate in several routine applications. Since neodymium acetate is not toxic, not radioactive and easy to use, we foresee neodymium will replace uranyl in many EM sample preparation applications worldwide.

摘要

醋酸双氧铀是电子显微镜（EM）中的标准对比剂，但它具有毒性和放射性。我们推测醋酸钕可能可以替代醋酸双氧铀作为对比剂，我们发现醋酸钕确实可以在几种常规应用中替代醋酸双氧铀。由于醋酸钕没有毒性、不具有放射性且易于使用，我们预计醋酸钕将在全球许多 EM 样品制备应用中取代醋酸双氧铀。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1c/7160090/f3a699a8e69d/418_2020_1846_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1c/7160090/55594960ae7a/418_2020_1846_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1c/7160090/0a8cc731c540/418_2020_1846_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1c/7160090/a2b29451accf/418_2020_1846_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1c/7160090/f3a699a8e69d/418_2020_1846_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1c/7160090/55594960ae7a/418_2020_1846_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1c/7160090/0a8cc731c540/418_2020_1846_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1c/7160090/a2b29451accf/418_2020_1846_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1c/7160090/f3a699a8e69d/418_2020_1846_Fig4_HTML.jpg

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