Zeng Yiming, Wang Xiangdong, Zhang Jiaqiang
Department of Pulmonary and Critical Care Medicine, Clinical Center for Molecular Diagnosis and Therapy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Centre for Tumor Diagnosis and Therapy, Jinshan Hospital, Fudan University Shanghai Medical College, Shanghai, China.
Cell Biol Toxicol. 2020 Feb;36(1):1-3. doi: 10.1007/s10565-020-09515-7. Epub 2020 Feb 1.
Single-cell biomedicine, a new merging discipline of cell biology and medicine to improve the life quality of patients, gains high priority in cell biology and toxicology. Single-cell nuclear elements are specially focused and headlined to understand regulatory mechanisms by which transcriptional factors, DNA elements, and genome organization interact with each other and contribute to the developmental evolution and dynamic formation of genotoxicity. Cell molecular phenomics, clonal genotypes, and structural metamorphoses during the cell cycle at single-cell level provide deep insights to understanding mechanism-based bridges between cell biology and toxicology, between cell sensitive and resistance, and between chronic diseases and cancer.
单细胞生物医学是细胞生物学与医学融合而成的一门新学科，旨在提高患者的生活质量，在细胞生物学和毒理学领域备受关注。单细胞核元件受到特别关注并成为研究重点，以了解转录因子、DNA元件和基因组组织相互作用并促进基因毒性的发育演变和动态形成的调控机制。单细胞水平上细胞周期中的细胞分子表型组学、克隆基因型和结构变形，为理解细胞生物学与毒理学之间、细胞敏感与抗性之间以及慢性病与癌症之间基于机制的桥梁提供了深刻见解。
