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How far is single-cell sequencing from clinical application?

作者信息

Zhang Jiaqiang, Wang William, Huang Jianan, Wang Xiangdong, Zeng Yiming

机构信息

Department of Anesthesiology and Perioperative Medicine, Center for Clinical Single Cell Biomedicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Center for Tumor Diagnosis and Therapy, Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical College, Jinshan Hospital, Fudan University, Shanghai, China.

出版信息

Clin Transl Med. 2020 Jul;10(3):e117. doi: 10.1002/ctm2.117. Epub 2020 Jul 5.

DOI:10.1002/ctm2.117
PMID:32623809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7418798/
Abstract
摘要

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本文引用的文献

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Molecular mechanisms, off-target activities, and clinical potentials of genome editing systems.基因组编辑系统的分子机制、脱靶活性及临床应用潜力
Clin Transl Med. 2020 Jan;10(1):412-426. doi: 10.1002/ctm2.34.
2
Multidisciplinary therapy strategy of precision medicine in clinical practice.临床实践中精准医学的多学科治疗策略
Clin Transl Med. 2020 Jan;10(1):116-124. doi: 10.1002/ctm2.15. Epub 2020 Mar 31.
3
Eleven grand challenges in single-cell data science.单细胞数据科学的 11 大挑战。
Genome Biol. 2020 Feb 7;21(1):31. doi: 10.1186/s13059-020-1926-6.
4
Single-cell biomedicine: roles of single-cell nuclear elements.单细胞生物医学：单细胞核元件的作用
Cell Biol Toxicol. 2020 Feb;36(1):1-3. doi: 10.1007/s10565-020-09515-7. Epub 2020 Feb 1.
5
Multi-omics profiling of mouse gastrulation at single-cell resolution.单细胞分辨率下的小鼠原肠胚形成的多组学分析。
Nature. 2019 Dec;576(7787):487-491. doi: 10.1038/s41586-019-1825-8. Epub 2019 Dec 11.
6
Current best practices in single-cell RNA-seq analysis: a tutorial.单细胞 RNA 测序分析的当前最佳实践：教程。
Mol Syst Biol. 2019 Jun 19;15(6):e8746. doi: 10.15252/msb.20188746.
7
Simultaneous Profiling of mRNA Transcriptome and DNA Methylome from a Single Cell.从单个细胞同时分析mRNA转录组和DNA甲基化组
Methods Mol Biol. 2019;1979:363-377. doi: 10.1007/978-1-4939-9240-9_21.
8
Linked-read analysis identifies mutations in single-cell DNA-sequencing data.关联读取分析可鉴定单细胞 DNA 测序数据中的突变。
Nat Genet. 2019 Apr;51(4):749-754. doi: 10.1038/s41588-019-0366-2. Epub 2019 Mar 18.
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Cell-cell communication: old mystery and new opportunity.细胞间通讯：古老的谜团与新的机遇。
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