Graduate Program in Health and Life Sciences, Universidade Franciscana (UFN), 1175 Silva Jardim St, Santa Maria, RS, 97010-491, Brazil.
Graduate Program in Pharmacology, Universidade Federal de Santa Maria (UFSM), 1000 Roraima Ave, Santa Maria, RS, 97105-900, Brazil.
Eur Arch Paediatr Dent. 2021 Feb;22(1):21-28. doi: 10.1007/s40368-020-00509-x. Epub 2020 Feb 1.
The aim of the present study was to investigate the effect of cerebral palsy and dental caries on dental plaque index, salivary parameters and oxidative stress in children and adolescents.
Seventy children and adolescents aged 2-20 years were divided into four groups: neurotypical controls-inactive caries (NCIC; n = 19); neurotypical controls-active caries (NCAC; n = 16); cerebral palsy-inactive caries (CPIC; n = 19); and cerebral palsy-active caries (CPAC; n = 16). The visible dental plaque index was determined after drying the tooth surfaces and without any mechanical or chemical disclosing methods. Salivary pH and buffer capacity were measured 1 hour after collection using a digital pH meter. Saliva was used to evaluate oxidative status based on the levels of reactive species, lipid peroxidation and non-enzymatic antioxidants (reduced glutathione and vitamin C).
The CPIC and CPAC groups had lower salivary pH and a higher visible dental plaque index. CP was also associated with an increase in salivary levels of markers of oxidative stress and the modulation of salivary levels of non-enzymatic antioxidants.
Cerebral palsy exerts an influence on the salivary profile, oral health and oxidative stress. The individuals with CP had more acidic saliva and a higher dental plaque index, which were positively correlated with caries activity. CP was associated with high salivary levels of reactive species and lipid peroxidation, demonstrating an imbalance in salivary redox that was particularly associated with caries activity. These factors facilitate the development of oral diseases in individuals with cerebral palsy.
本研究旨在探讨脑瘫和龋齿对儿童和青少年的菌斑指数、唾液参数和氧化应激的影响。
将 70 名 2-20 岁的儿童和青少年分为四组：神经典型对照组-无龋（NCIC；n=19）；神经典型对照组-有龋（NCAC；n=16）；脑瘫-无龋（CPIC；n=19）；脑瘫-有龋（CPAC；n=16）。在不使用任何机械或化学显影方法干燥牙面后，确定可见菌斑指数。收集后 1 小时，使用数字 pH 计测量唾液 pH 值和缓冲能力。根据活性物质、脂质过氧化和非酶抗氧化剂（还原型谷胱甘肽和维生素 C）的水平，使用唾液评估氧化状态。
CPIC 和 CPAC 组的唾液 pH 值较低，可见菌斑指数较高。脑瘫还与唾液中氧化应激标志物水平升高以及非酶抗氧化剂唾液水平的调节有关。
脑瘫对唾液状况、口腔健康和氧化应激有影响。脑瘫患者的唾液更酸，菌斑指数更高，这与龋齿的活跃性呈正相关。脑瘫与唾液中活性物质和脂质过氧化水平升高有关，表明唾液氧化还原失衡，特别是与龋齿的活跃性有关。这些因素促进了脑瘫患者口腔疾病的发展。
