Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235, West Bengal, India.
Org Biomol Chem. 2020 Mar 4;18(9):1728-1732. doi: 10.1039/c9ob02756d.
A simple and efficient method for the directed amidation of a wide range of 2-arylindazoles has been established for the first time through a rhodium-catalyzed C-H activation reaction with alkyl, aryl and heteroaryl dioxazolones. A series of N-(2-(2H-indazol-2-yl)phenyl)acetamide derivatives were synthesized in excellent yields. A mechanistic study was conducted to describe C-H bond cleavage which is likely to be involved in the rate determining step.
首次通过铑催化的 C-H 活化反应，用烷基、芳基和杂芳基二恶唑酮，建立了一种简单高效的导向酰胺化方法，用于合成各种 2-芳基吲唑。一系列 N-(2-(2H-吲唑-2-基)苯基)乙酰胺衍生物以优异的收率合成。进行了一项机理研究来描述 C-H 键的断裂，该断裂可能涉及速率决定步骤。
