Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA.
Microarray and Genome Informatics Group, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA.
RNA Biol. 2020 May;17(5):630-636. doi: 10.1080/15476286.2020.1724715. Epub 2020 Feb 12.
MicroRNAs (miRNAs) are small RNAs that regulate mRNA expression and have been targeted as biomarkers of organ damage and disease. To explore the utility of miRNAs to assess injury to specific tissues, a tissue atlas of miRNA abundance was constructed. The at tlas of issue-specific and nriched (RATEmiRs) catalogues miRNA sequencing data from 21 and 23 tissues in male and female Sprague-Dawley rats, respectively. RATEmiRs identifies tissue-enriched (TE), tissue-specific (TS), or organ-specific (OS) miRNAs via comparisons of one or more tissue or organ vs others. We provide a brief overview of RATEmiRs and present how to use it to detect miRNA expression abundance of candidate biomarkers as well as to compare the expression of miRNAs between rat and human. The database is available at https://www.niehs.nih.gov/ratemirs/.
微小 RNA（miRNAs）是调节 mRNA 表达的小 RNA，已被作为器官损伤和疾病的生物标志物进行靶向研究。为了探索 miRNA 用于评估特定组织损伤的效用，构建了 miRNA 丰度的组织图谱。该图谱（RATEmiRs）编目了雄性和雌性 Sprague-Dawley 大鼠 21 种和 23 种组织的 miRNA 测序数据。RATEmiRs 通过比较一个或多个组织或器官与其他组织或器官，鉴定组织富集（TE）、组织特异性（TS）或器官特异性（OS）miRNAs。我们简要概述了 RATEmiRs，并介绍了如何使用它来检测候选生物标志物的 miRNA 表达丰度，以及比较大鼠和人类之间的 miRNA 表达。该数据库可在 https://www.niehs.nih.gov/ratemirs/ 上获得。
