Chen Yiya, He Zhifen, Mao Yu, Chen Hao, Zhou Jiawei, Hess Robert F
School of Ophthalmology and Optometry and Eye Hospital, State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University, Wenzhou, China.
McGill Vision Research, Department of Ophthalmology and Visual Sciences, McGill University, Montreal, QC, Canada.
Front Neurosci. 2020 Jan 15;13:1364. doi: 10.3389/fnins.2019.01364. eCollection 2019.
To determine if benefits from occlusion therapy are due to decreased suppression from the fellow eye in children with amblyopia.
Ten newly diagnosed amblyopes (7.2 ± 1.4 years old), two with strabismus and eight with anisometropia, participated. Patients were first given a 2-month period of refractive adaptation, followed by occlusion therapy (i.e., patching their fellow eye with an opaque patch for 4 h/day). Visual acuity of the amblyopic eye and interocular suppression were measured before and after 0.5, 1, 2, 4, and 6 months of occlusion therapy. We quantified interocular suppression with a binocular phase combination task.
Visual acuity (in logMAR) improved from 0.50 ± 0.22 (mean ± SD) to 0.33 ± 0.20 for patients who finished a short-term (2 months) occlusion (A1-A10), from 0.53 ± 0.20 to 0.32 ± 0.22 for patients who finished a medium-term (4 months) occlusion (A1-A9), and from 0.48 ± 0.19 to 0.22 ± 0.10 for patients who finished a long-term (6 months) occlusion (A1-A8). Although their visual acuity significantly improved, their degree of suppression, which was abnormal in all cases, did not change consistently. This was true in all durations of occlusion therapy.
Reduced suppression from the fixing eye might not be result from occlusion therapy.
确定在弱视儿童中，遮盖疗法的益处是否源于对侧眼抑制的降低。
十名新诊断的弱视患者（7.2±1.4岁）参与研究，其中两名患有斜视，八名患有屈光参差。患者首先接受为期2个月的屈光适应期，随后进行遮盖疗法（即用不透明眼罩遮盖对侧眼4小时/天）。在遮盖疗法进行0.5、1、2、4和6个月之前及之后，测量弱视眼的视力和双眼间抑制情况。我们通过双眼相位组合任务对双眼间抑制进行量化。
完成短期（2个月）遮盖的患者（A1 - A10），视力（以logMAR表示）从0.50±0.22（平均值±标准差）提高到0.33±0.20；完成中期（4个月）遮盖的患者（A1 - A9），视力从0.53±0.20提高到0.32±0.22；完成长期（6个月）遮盖的患者（A1 - A8），视力从0.48±0.19提高到0.22±0.10。尽管他们的视力显著提高，但所有病例中均异常的抑制程度并未持续改变。在所有遮盖疗法持续时间内均是如此。
来自注视眼的抑制降低可能并非遮盖疗法的结果。
