Tao Chunwen, He Zhifen, Chen Yiya, Zhou Jiawei, Hess Robert F
State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Department of Ophthalmology and Visual Sciences, McGill Vision Research, McGill University, Montreal, QC, Canada.
Front Neurosci. 2020 Jun 26;14:625. doi: 10.3389/fnins.2020.00625. eCollection 2020.
Recently, Lunghi et al. (2016) showed that amblyopic eye's visual acuity after 2 months of occlusion therapy could be predicted by a homeostatic plasticity, that is, the temporary shift of perceptual eye dominance observed after a 2-h monocular deprivation, in children with anisometropic amblyopia. In this study, we assess whether the visual acuity improvement of the amblyopic eye measured after 2 months of occlusion therapy could be predicted by this plasticity.
Seven children (6.86 ± 1.46 years old; SD) with anisometropic amblyopia participated in this study. All patients were newly diagnosed and had no treatment history before participating in our study. They finished 2 months of refractive adaptation and then received a 4-h daily fellow eye patching therapy with an opaque patch for a 2-month period. Best-corrected visual acuity of the amblyopic eye was measured before and after the patching therapy. The homeostatic plasticity was assessed by measuring the temporary shift of perceptual eye dominance from 2-h occlusion of the amblyopic eye before treatment. A binocular phase combination paradigm was used for this study.
We found that there was no significant correlation between the temporary shift of perceptual eye dominance observed after 2-h occlusion of the amblyopic eye and the improvement in visual acuity in the amblyopic eye from 2 months of classical patching therapy. This result, although in disagreements with the conclusions of Lunghi et al. involving the short-term patching of the amblyopic eye, is in fact consistent with a reanalysis of Lunghi and colleagues' data.
The short-term changes in perceptual eye dominance as a result of short-term monocular deprivation do not provide an index of cortical plasticity in the general sense such that they are able to predict acuity outcomes from longer-term classical patching.
最近，伦吉等人（2016年）表明，对于屈光参差性弱视儿童，通过一种稳态可塑性，即单眼剥夺2小时后观察到的感知性眼优势的暂时转移，可以预测遮盖疗法2个月后弱视眼的视力。在本研究中，我们评估这种可塑性是否可以预测遮盖疗法2个月后测得的弱视眼视力改善情况。
7名患有屈光参差性弱视的儿童（6.86±1.46岁；标准差）参与了本研究。所有患者均为新诊断病例，在参与我们的研究之前没有治疗史。他们完成了2个月的屈光适应，然后接受为期2个月的每天4小时健眼遮盖治疗，使用不透明眼罩。在遮盖治疗前后测量弱视眼的最佳矫正视力。通过测量治疗前弱视眼2小时遮盖后感知性眼优势的暂时转移来评估稳态可塑性。本研究使用了双眼相位组合范式。
我们发现，弱视眼2小时遮盖后观察到的感知性眼优势的暂时转移与传统遮盖疗法2个月后弱视眼视力的改善之间没有显著相关性。这一结果虽然与伦吉等人关于弱视眼短期遮盖的结论不一致，但实际上与对伦吉及其同事数据的重新分析结果一致。
短期单眼剥夺导致的感知性眼优势的短期变化并不能提供一般意义上的皮质可塑性指标，因此无法预测长期传统遮盖疗法的视力结果。
