Department of Cardiovascular Medicine, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, P.R. China.
Transl Res. 2012 Aug;160(2):131-6. doi: 10.1016/j.trsl.2012.01.013. Epub 2012 Feb 2.
Body fat is an important source of adipokines not only in association with energy balance, but also with inflammatory and immune responses. This study investigated the relationship between serum levels of adipokines and coronary artery aneurysm in patients with Kawasaki disease (KD). Levels of leptin, adiponectin, and resistin were measured in 165 cases, including 4 groups: the control group (n = 85), KD with normal coronary arteries (n = 41), KD with dilatation and/or ectasia (n = 31), and KD with coronary aneurysm (n = 8). White blood cells counts (WBC), red blood cells counts (RBC), hemoglobin (HB), Hematocrit (Hct), platelet count, C reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were tested in children. Levels of adiponectin and resistin levels were significantly elevated; hemoglobin significantly decreased in the group of KD with coronary aneurysm compared with the controls or other KD subgroups. There were markedly positive relationships between levels of resistin and CRP, and negative relationships between levels of resistin and RBC in patients with KD. Levels of adiponectin, resistin, and hemoglobin were associated with the development of coronary aneurysm in children with KD. The up-regulation of resistin secreted from adipose tissue may be closely linked to up-regulation of systemic proinflammatory markers in acute KD.
体脂肪不仅与能量平衡有关，还与炎症和免疫反应有关，是一种重要的脂肪因子来源。本研究探讨了川崎病（KD）患者血清脂肪因子水平与冠状动脉瘤之间的关系。测量了 165 例患者（包括 4 组）的瘦素、脂联素和抵抗素水平，对照组（n=85）、KD 伴正常冠状动脉（n=41）、KD 伴扩张和/或扩张（n=31）和 KD 伴冠状动脉瘤（n=8）。检测了儿童的白细胞计数（WBC）、红细胞计数（RBC）、血红蛋白（HB）、红细胞压积（Hct）、血小板计数、C 反应蛋白（CRP）和红细胞沉降率（ESR）。与对照组或其他 KD 亚组相比，冠状动脉瘤组的脂联素和抵抗素水平显著升高，血红蛋白显著降低。KD 患者的抵抗素水平与 CRP 呈显著正相关，与 RBC 呈显著负相关。脂联素、抵抗素和血红蛋白水平与 KD 儿童冠状动脉瘤的发生有关。脂肪组织分泌的抵抗素上调可能与急性 KD 中系统性促炎标志物的上调密切相关。
