Gruenwald Joerg, Bongartz Udo, Bothe Gordana, Uebelhack Ralf
Analyze & Realize GmbH, D-13467 Berlin, Germany.
Charité Hospital, D-10117 Berlin, Germany.
Exp Ther Med. 2020 Feb;19(2):1490-1499. doi: 10.3892/etm.2019.8378. Epub 2019 Dec 27.
Cardiovascular diseases are the main cause of death in the industrialized world, with the main risk factors being elevated blood pressure and blood lipid levels, leading to arterial stiffness and arteriosclerosis. In this study, we examined the effect of aged garlic extract (AGE) on arterial elasticity, using the EndoPAT™ technology in subjects with slightly elevated blood pressure. This randomized double-blind, placebo-controlled clinical trial examined 57 subjects over a period of 12 weeks, with EndoPAT™ measurements taken at 0 and 12 weeks; in addition, changes in blood pressure were analyzed. The positive effect of AGE on blood pressure values previously reported was confirmed. The results revealed a significant decrease in blood pressure in the AGE group, and in particular diastolic blood pressure. Using the EndoPAT™ technology, the augmentation index (AI) was analyzed, which measures arterial stiffness calculated via pulse waveform analysis of the PAT signal; lower AI values reflect better arterial elasticity. The AGE group exhibited a significant improvement in arterial elasticity, measured as AI, by 21.6%. The result of this well-controlled clinical trial confirmed the positive effect of AGE on blood pressure. To the best of our knowledge, for the first time, the effect of AGE on arterial elasticity could be proven using the EndoPAT™ methodology. These results not only demonstrate the positive effects of AGE on the relevant risk factors of cardiovascular diseases, but also the direct effect on arterial elasticity. These data clearly indicate that AGE may exert several positive direct effects on the development and progression of cardiovascular diseases.
心血管疾病是工业化国家的主要死因，主要风险因素是血压和血脂水平升高，导致动脉僵硬和动脉硬化。在本研究中，我们使用EndoPAT™技术，在血压略有升高的受试者中研究了陈年大蒜提取物（AGE）对动脉弹性的影响。这项随机双盲、安慰剂对照的临床试验对57名受试者进行了为期12周的研究，在第0周和第12周进行EndoPAT™测量；此外，还分析了血压变化。此前报道的AGE对血压值的积极作用得到了证实。结果显示，AGE组的血压显著下降，尤其是舒张压。使用EndoPAT™技术分析了增强指数（AI），该指数通过对PAT信号的脉搏波形分析来计算动脉僵硬度；较低的AI值反映出更好的动脉弹性。以AI衡量，AGE组的动脉弹性显著改善了21.6%。这项严格控制的临床试验结果证实了AGE对血压的积极作用。据我们所知，首次使用EndoPAT™方法证明了AGE对动脉弹性的影响。这些结果不仅证明了AGE对心血管疾病相关风险因素的积极作用，也证明了其对动脉弹性的直接作用。这些数据清楚地表明，AGE可能对心血管疾病的发生和发展产生多种积极的直接影响。
