Demiral Sezer S
Health Science University, Tepecik Training and Research Hospital - Internal Medicine, Gaziler Caddesi Yenişehir-Konak, Turkey.
Acta Endocrinol (Buchar). 2019 Jul-Sep;15(3):360-363. doi: 10.4183/aeb.2019.360.
The aim of this study was to investigate the effects of vitamin D deficiency on insulin resistance in patients with non-diabetic chronic kidney disease.
A total of 104 patients with non-diabetic, stage 2 and 3 chronic kidney disease, who had presented to the outpatient clinic during 2 winters, were included in the study. HOMA-IR rate of > 2.6 was accepted as insulin resistance. Severe 25-OH-vitamin D deficiency was defined as < 10 ng/mL, and 10-30 ng/mL was defined as vitamin D insufficiency. The difference in insulin resistance between the patients determined as having severe vitamin D deficiency and vitamin D insufficiency was investigated.
Severe vitamin D deficiency was observed to be higher among women (61.8% . 38.2%), whereas insufficiency was more common among men (63.3% . 26.7%, p<0.05). Insulin resistance was observed to be higher in the group with severe deficiency (11.5 . 7.82, p<0.05). Insulin resistance was observed in 60% and 36.7% of the groups with severe deficiency and insufficiency, respectively (p<0.05).
Severe vitamin D deficiency had resulted in insulin resistance at a greater rate compared to vitamin D insufficiency in patients with non-diabetic chronic kidney disease (stage 2-3).
本研究旨在调查维生素D缺乏对非糖尿病慢性肾脏病患者胰岛素抵抗的影响。
共有104例2期和3期非糖尿病慢性肾脏病患者纳入本研究，这些患者在两个冬季期间到门诊就诊。HOMA-IR率>2.6被视为胰岛素抵抗。严重25-羟基维生素D缺乏定义为<10 ng/mL，10-30 ng/mL定义为维生素D不足。研究了被确定为严重维生素D缺乏和维生素D不足的患者之间胰岛素抵抗的差异。
观察到严重维生素D缺乏在女性中更高（61.8%对38.2%），而不足在男性中更常见（63.3%对26.7%，p<0.05）。观察到严重缺乏组的胰岛素抵抗更高（11.5对7.82，p<0.05）。严重缺乏组和不足组的胰岛素抵抗发生率分别为60%和36.7%（p<0.05）。
在非糖尿病慢性肾脏病（2-3期）患者中，与维生素D不足相比，严重维生素D缺乏导致胰岛素抵抗的发生率更高。
