Tan Shawn Zheng Kai, Fung Man-Lung, Koh Junhao, Chan Ying-Shing, Lim Lee Wei
School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Aging Dis. 2020 Feb 1;11(1):179-190. doi: 10.14336/AD.2019.0511. eCollection 2020 Feb.
Deep brain stimulation (DBS) is a promising treatment for many memory-related disorders including dementia, anxiety, and addiction. However, the use of DBS can be a paradoxical conundrum-dementia treatments aim to improve memory, whereas anxiety or addiction treatments aim to suppress maladaptive memory. In this review, the key hypotheses on how DBS affects memory are highlighted. We consolidate the findings and conclusions from the current research on the effects of DBS on memory in attempt to make sense of the bidirectional nature of DBS in disrupting and enhancing memory. Based on the current literature, we hypothesize that the timing of DBS plays a key role in its contradictory effects, and therefore, we propose a consolidated model of how DBS can both disrupt and enhance memory.
深部脑刺激（DBS）是一种对包括痴呆、焦虑和成瘾在内的许多与记忆相关的疾病都很有前景的治疗方法。然而，DBS的使用可能是一个自相矛盾的难题——痴呆治疗旨在改善记忆，而焦虑或成瘾治疗旨在抑制适应不良的记忆。在这篇综述中，重点介绍了关于DBS如何影响记忆的关键假设。我们整合了当前关于DBS对记忆影响的研究结果和结论，试图理解DBS在破坏和增强记忆方面的双向性质。基于当前的文献，我们假设DBS的时机在其矛盾效应中起关键作用，因此，我们提出了一个关于DBS如何既能破坏又能增强记忆的综合模型。
