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你的体液有多咸?住院医师对儿科维持性静脉输液的处方习惯

How Salty Are Your Fluids? Pediatric Maintenance IV Fluid Prescribing Practices Among Hospitalists.

作者信息

Hall Alan M, Ayus Juan C, Moritz Michael L

机构信息

Division of Hospital Medicine and Pediatrics, University of Kentucky College of Medicine, Lexington, KY, United States.

Renal Consultants of Houston, Houston, TX, United States.

出版信息

Front Pediatr. 2020 Jan 15;7:549. doi: 10.3389/fped.2019.00549. eCollection 2019.

DOI:10.3389/fped.2019.00549
PMID:32010650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6974532/
Abstract

The primary goal of this study was to assess current maintenance intravenous fluid (mIVF) prescribing practices of pediatric hospitalists after the release of the American Academy of Pediatrics Clinical Practice Guideline (AAP CPG), specifically assessing the rates of various isotonic vs. hypotonic solutions used in discrete age groups and in common clinical scenarios associated with anti-diuretic hormone (ADH) excess and hyponatremia. We hypothesized that isotonic fluids would be selected in most cases outside of the neonatal period. A voluntary and anonymous survey was distributed to the LISTSERV® for the AAP Section on Hospital Medicine. There were 402 total responses (10.1% response rate) with the majority of respondents being pediatric hospitalists. Isotonic solutions were preferred by respondents in older children compared to younger age groups, at 87.8% for the 1-18 years age group compared to 66.3% for the 28 days to 1 year age group and 10.6% for the younger than 28 days age group (all values <0.0001). When presented with disease states associated with ADH excess, isotonic fluids were preferred in higher percentages in all age groups except in children younger than 28 days when 0.45% sodium chloride was preferred; 0.2% sodium chloride was rarely chosen. Overall, based on survey responses, pediatric hospitalists are following the 2018 AAP CPG on mIVF and are more likely to choose isotonic fluids as their primary mIVF in pediatric patients outside of the neonatal period, including in scenarios of excess ADH. Isotonic fluids use seems to be higher with increasing age and hypotonic fluids are more commonly chosen in the neonatal period.

摘要

本研究的主要目标是评估美国儿科学会临床实践指南(AAP CPG)发布后,儿科住院医师当前的维持性静脉输液(mIVF)处方实践,具体评估不同年龄组以及与抗利尿激素(ADH)分泌过多和低钠血症相关的常见临床场景中使用各种等渗与低渗溶液的比例。我们假设在新生儿期以外的大多数情况下会选择等渗液。向AAP医院医学分会的LISTSERV®分发了一份自愿且匿名的调查问卷。共收到402份回复(回复率为10.1%),大多数受访者为儿科住院医师。与较年幼的年龄组相比,年龄较大儿童的受访者更倾向于等渗溶液,1 - 18岁年龄组的比例为87.8%,而28天至1岁年龄组为66.3%,小于28天年龄组为10.6%(所有值<0.0001)。当面对与ADH分泌过多相关的疾病状态时,除了小于28天的儿童更倾向于0.45%氯化钠溶液外,所有年龄组中选择等渗液的比例更高;很少选择0.2%氯化钠溶液。总体而言,根据调查回复,儿科住院医师遵循2018年AAP关于mIVF的CPG,并且在新生儿期以外的儿科患者中,更有可能选择等渗液作为主要的mIVF,包括在ADH分泌过多的情况下。随着年龄增长,等渗液的使用似乎更高,而在新生儿期更常选择低渗液。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fbc/6974532/07d6a81c6134/fped-07-00549-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fbc/6974532/63225c22d183/fped-07-00549-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fbc/6974532/07d6a81c6134/fped-07-00549-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fbc/6974532/63225c22d183/fped-07-00549-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fbc/6974532/07d6a81c6134/fped-07-00549-g0002.jpg

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本文引用的文献

1
Clinical Practice Guideline: Maintenance Intravenous Fluids in Children.临床实践指南:儿童维持静脉补液。
Pediatrics. 2018 Dec;142(6). doi: 10.1542/peds.2018-3083.
2
Balanced Crystalloids versus Saline in Noncritically Ill Adults.非危重症成年患者使用平衡晶体液与生理盐水的比较。
N Engl J Med. 2018 Mar 1;378(9):819-828. doi: 10.1056/NEJMoa1711586. Epub 2018 Feb 27.
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Balanced Crystalloids versus Saline in Critically Ill Adults.重症成年患者中平衡晶体液与生理盐水的比较
平衡晶体液与生理盐水用于重症哮喘儿童的比较
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Children (Basel). 2021 Sep 8;8(9):785. doi: 10.3390/children8090785.
N Engl J Med. 2018 Mar 1;378(9):829-839. doi: 10.1056/NEJMoa1711584. Epub 2018 Feb 27.
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Maintenance Intravenous Fluids in Acutely Ill Patients.急性病患者的维持性静脉输液
N Engl J Med. 2015 Oct;373(14):1350-60. doi: 10.1056/NEJMra1412877.
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Isotonic versus hypotonic solutions for maintenance intravenous fluid administration in children.等渗溶液与低渗溶液用于儿童维持性静脉输液
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6
Hypotonic versus isotonic fluids in hospitalized children: a systematic review and meta-analysis.住院儿童使用低渗液与等渗液的比较:一项系统评价和荟萃分析。
J Pediatr. 2014 Jul;165(1):163-169.e2. doi: 10.1016/j.jpeds.2014.01.040. Epub 2014 Feb 28.
7
Isotonic versus hypotonic maintenance IV fluids in hospitalized children: a meta-analysis.等渗与低渗维持 IV 液在住院儿童中的比较:一项荟萃分析。
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8
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Korean J Pediatr. 2013 Jul;56(7):282-5. doi: 10.3345/kjp.2013.56.7.282. Epub 2013 Jul 19.
9
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Acta Paediatr. 2012 Oct;101(10):e465-8. doi: 10.1111/j.1651-2227.2012.02780.x. Epub 2012 Jul 27.
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