James H K, McDonnell F, Lewis Thomas W
The Kennel Club, London, United Kingdom.
School of Veterinary Medicine and Science, The University of Nottingham, Nottingham, United Kingdom.
Front Vet Sci. 2020 Jan 15;6:490. doi: 10.3389/fvets.2019.00490. eCollection 2019.
Hip and elbow dysplasia are common disorders in larger dog breeds and crosses, and a known contributory factor to osteoarthritis, lameness and reduced mobility. Screening schemes evaluating the severity of hip and elbow dysplasia in the UK are administered by the British Veterinary Association (BVA) and the Kennel Club (KC). The BVA/KC Hip Dysplasia scoring scheme is over 50 years old, having originated in 1965, and has operated in its current form since 1983. The BVA/KC Elbow Dysplasia grading scheme commenced more recently in 1998 and is based on the International Elbow Working Group guidelines. Hip score and elbow grade data on a considerable number of dogs in the UK have been generated from these two screening schemes. This study analyses data from dogs of six breeds scored from 1990 to present, to establish any determinable trends in hip score and elbow grade parameters, and to examine whether the implementation of such schemes has had a positive influence on hip and elbow health. A range of criteria, including the rate of participation in the screening schemes, hip score and elbow grade parameters (e.g., median, mean, standard deviation), and estimated breeding values (EBVs) were analyzed, both in the overall population and also among breeding animals. The results show a general decline in hip score parameters (median, mean, standard deviation, and 75th percentile), revealing a reduction in the prevalence and severity of hip dysplasia. There was a more modest decline in mean elbow grade within breeds. The proportion of sires and dams (of dogs born per year) with no hip score or elbow grade fell substantially over time, demonstrating good participation in the screening schemes. In most breeds, the scores of sires and dams are demonstrably improving. There is a declining genetic trend as ascertained by EBVs for both hip scores and elbow grades in most breeds, implying that the improvement observed is due in part to selection for improvement in hip and elbow health as described by the respective screening schemes.
髋关节和肘关节发育异常是大型犬种及其杂交品种常见的病症,也是导致骨关节炎、跛行和行动能力下降的一个已知因素。英国评估髋关节和肘关节发育异常严重程度的筛查计划由英国兽医协会(BVA)和养犬俱乐部(KC)负责实施。BVA/KC髋关节发育异常评分方案已有50多年历史,始于1965年,自1983年起以现行形式运行。BVA/KC肘关节发育异常分级方案于1998年开始实施,基于国际肘关节工作组的指导方针。通过这两项筛查计划,已经收集了英国大量犬只的髋关节评分和肘关节分级数据。本研究分析了1990年至今六个犬种的犬只数据,以确定髋关节评分和肘关节分级参数中任何可确定的趋势,并研究此类计划的实施是否对髋关节和肘关节健康产生了积极影响。分析了一系列标准,包括筛查计划的参与率、髋关节评分和肘关节分级参数(如中位数、均值、标准差)以及估计育种值(EBV),涵盖总体犬只以及繁殖动物。结果显示,髋关节评分参数(中位数、均值、标准差和第75百分位数)普遍下降,表明髋关节发育异常的患病率和严重程度有所降低。各犬种内平均肘关节分级的下降幅度较小。随着时间推移,无髋关节评分或肘关节分级的公犬和母犬(每年出生的犬只)比例大幅下降,表明对筛查计划的参与度良好。在大多数犬种中,公犬和母犬的评分明显提高。通过EBV确定,大多数犬种的髋关节评分和肘关节分级的遗传趋势呈下降趋势,这意味着观察到的改善部分归因于按照各自筛查计划对髋关节和肘关节健康改善的选择。