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两种镇静方案用于髋关节发育不良犬诊断性放射摄影的比较。

Comparison of two sedation protocols for diagnostic radiography in dogs with hip dysplasia.

作者信息

Beier Suzane Lilian, de Lima Marcos Paulo Antunes, de Sousa Felipe Gaia, Silva Renata Andrade, Fagundes Natália, Bovi Milena Fascina, Tôrres Renato Cesar Sacchetto

机构信息

Department of Veterinary Clinic and Surgery, School of Veterinary Medicine, Federal University of Minas Gerais, 6627 Antônio Carlos Av, Pampulha, Belo Horizonte 31270-901, Minas Gerais, Brazil.

出版信息

Vet Anim Sci. 2023 Apr 25;20:100294. doi: 10.1016/j.vas.2023.100294. eCollection 2023 Jun.

Abstract

Hip dysplasia is an alteration with a high incidence in large dogs. The aim of the study was to compare the association of xylazine or dexmedetomidine with fentanyl for radiography with joint distractor for the diagnosis of hip dysplasia. Fifteen healthy dogs, German Shepherd and Belgian Shepherd, were randomly submitted to treatments 0.2 mg/kg xylazine + 2.5 µg/kg fentanyl (XF) or 2 µg/kg dexmedetomidine + 2.5 µg/kg fentanyl (DF), intravenously. HR, , SAP, MAP, DAP and TR were evaluated at intervals of 5 min before and after the administration of treatments; pH, PaCO, PaO, BE, HCO, SaO, Na, and Hb at 5 and 15 min after treatment administration; and the quality of sedation at intervals of 5 min after administration of treatments. Latency, duration, and recovery times were also compared. The HR values showed a significant reduction in both groups, as well as pH, PaCO, PaO and SaO. Latency, duration and recovery times, and quality of sedation did not differ statistically between groups. Xylazine and fentanyl or dexmedetomidine and fentanyl combinations provide adequate sedation and analgesia for performing diagnostic radiographic procedures for hip dysplasia. However, oxygen supplementation is recommended to increase protocol safety.

摘要

髋关节发育不良是大型犬中发病率较高的一种病变。本研究的目的是比较赛拉嗪或右美托咪定与芬太尼联合使用关节撑开器进行X线摄影以诊断髋关节发育不良的相关性。15只健康犬,德国牧羊犬和比利时牧羊犬,被随机静脉注射0.2mg/kg赛拉嗪 + 2.5μg/kg芬太尼(XF)或2μg/kg右美托咪定 + 2.5μg/kg芬太尼(DF)进行治疗。在给药前后每隔5分钟评估心率(HR)、收缩压(SAP)、平均动脉压(MAP)、舒张压(DAP)和呼吸频率(TR);给药后5分钟和15分钟评估pH值、动脉血二氧化碳分压(PaCO₂)、动脉血氧分压(PaO₂)、碱剩余(BE)、碳酸氢根(HCO₃⁻)、血氧饱和度(SaO₂)、钠(Na⁺)和血红蛋白(Hb);给药后每隔5分钟评估镇静质量。还比较了潜伏期、持续时间和恢复时间。两组的HR值均显著降低,pH值、PaCO₂、PaO₂和SaO₂也降低。两组之间的潜伏期、持续时间和恢复时间以及镇静质量在统计学上没有差异。赛拉嗪与芬太尼或右美托咪定与芬太尼联合使用可为髋关节发育不良的诊断性放射学检查提供足够的镇静和镇痛效果。然而,建议补充氧气以提高方案安全性。

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