Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Department of Aerospace Engineering, Mississippi State University, Starkville, MS 39762, USA.
Lab Chip. 2020 Mar 3;20(5):987-994. doi: 10.1039/c9lc01124b.
Acoustic tweezing technologies are gaining significant attention from the scientific communities due to their versatility and biocompatibility. This study presents acoustic tweezers based on circular, slanted-finger interdigital transducers (CSFITs), which can steer the propagation direction of surface acoustic waves (SAWs) by tuning the excitation frequency. The CSFITs based acoustic tweezers enable dynamic and reconfigurable manipulation of micro-objects using multi-tone excitation signals. Compared to traditional interdigital transducers that generate and control SAWs along one axis, the CSFITs allow for simultaneously generating and independently controlling SAWs propagating along multiple axes by changing the frequency composition and the phase information in a multi-tone excitation signal. Moreover, the CSFITs based acoustic tweezers can be used for patterning cells/particles in various distributions and translating them along complex paths. We believe that our design is valuable for cellular-scale biological applications, in which on-chip, contactless, biocompatible handling of bioparticles is needed.
基于圆形、倾斜指状叉指换能器（CSFIT）的声镊技术因其多功能性和生物相容性而受到科学界的广泛关注。本研究提出了基于 CSFIT 的声镊，通过调节激励频率可以控制表面声波（SAW）的传播方向。基于 CSFIT 的声镊可以使用多频激励信号对微物体进行动态和可重构的操作。与传统的仅在一个轴上产生和控制 SAW 的叉指换能器相比，CSFIT 通过改变多频激励信号中的频率组成和相位信息，可以同时产生并独立控制沿多个轴传播的 SAW。此外，基于 CSFIT 的声镊可用于对不同分布的细胞/颗粒进行图案化，并沿复杂路径进行平移。我们相信，我们的设计对于需要在芯片上进行非接触式、生物兼容的生物粒子处理的细胞级生物应用具有重要价值。
