Asthagiri Herbal Research Foundation, 162A, Perungudi Industrial Estate, Perungudi, Chennai 600096, India.
Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, Sharjah P.O. Box 26666, UAE.
Molecules. 2020 Jan 28;25(3):555. doi: 10.3390/molecules25030555.
The synthesis of metal nanoparticles using plant extracts is a very promising method in green synthesis. The medicinal value of leaves and the antimicrobial activity of metallic copper were combined in the present study to synthesize copper nanoparticles having a desirable added-value inorganic material. The use of a hydroalcoholic extract of leaves for the green synthesis of copper nanoparticles is an attractive method as it leads to the production of harmless chemicals and reduces waste. The total phenolic content in the leaves extract was 23.0 ± 0.3 mg gallic acid equivalent/g of dried leaves powder. The leaves extract was treated with a copper sulphate solution. A color change from brown to black indicates the formation of copper nanoparticles. Characterization of the synthesized copper nanoparticles was performed using ultraviolet-visible light (UV-Vis) spectrophotometry, Fourier-transform infrared (FTIR) spectrometry, high-resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The synthesized copper nanoparticles have an amorphous nature and particle size of 35.8-49.2 nm. We demonstrate that the M. oleifera leaves extract and the synthesized copper nanoparticles display considerable antioxidant activity. Moreover, the M. oleifera leaves extract and the synthesized copper nanoparticles exert considerable anti-bacterial activity against , , , and (MIC values for the extract: 500, 250, 250, and 250 µg/mL; MIC values for the copper nanoparticles: 500, 500, 500, and 250 µg/mL, respectively). Similarly, the M. oleifera leaves extract and the synthesized copper nanoparticles exert relatively stronger anti-fungal activity against , , , and (MIC values for the extract: 62.5, 62.5, 125, and 250 µg/mL; MIC values for the copper nanoparticles: 125, 125, 62.5, and 31.2 µg/mL, respectively). Our study reveals that the green synthesis of copper nanoparticles using a hydroalcoholic extract of leaves was successful. In addition, the synthesized copper nanoparticles can be potentially employed in the treatment of various microbial infections due to their reported antioxidant, anti-bacterial, and anti-fungal activities.
使用植物提取物合成金属纳米粒子是绿色合成中一种很有前途的方法。本研究将 叶片的药用价值与金属铜的抗菌活性相结合，合成了具有附加值的无机材料铜纳米粒子。使用 叶的水醇提取物来绿色合成铜纳米粒子是一种很有吸引力的方法，因为它可以产生无害的化学物质并减少浪费。 叶提取物中的总酚含量为 23.0 ± 0.3 mg 没食子酸当量/ g 干燥 叶粉。将 叶提取物与硫酸铜溶液一起处理。颜色从棕色变为黑色表明铜纳米粒子的形成。使用紫外-可见分光光度法（UV-Vis）、傅里叶变换红外（FTIR）光谱法、高分辨率透射电子显微镜（HRTEM）、扫描电子显微镜（SEM）和 X 射线衍射（XRD）对合成的铜纳米粒子进行了表征。合成的铜纳米粒子具有非晶态性质，粒径为 35.8-49.2nm。我们证明，M. oleifera 叶提取物和合成的铜纳米粒子具有相当大的抗氧化活性。此外，M. oleifera 叶提取物和合成的铜纳米粒子对 、 、 、 和 （提取物的 MIC 值：500、250、250 和 250 µg/mL；铜纳米粒子的 MIC 值：500、500、500 和 250 µg/mL）表现出相当大的抗菌活性。同样，M. oleifera 叶提取物和合成的铜纳米粒子对 、 、 、 和 （提取物的 MIC 值：62.5、62.5、125 和 250 µg/mL；铜纳米粒子的 MIC 值：125、125、62.5 和 31.2 µg/mL）表现出相对较强的抗真菌活性。我们的研究表明，使用 叶的水醇提取物成功地进行了铜纳米粒子的绿色合成。此外，由于报道的抗氧化、抗菌和抗真菌活性，合成的铜纳米粒子可潜在用于治疗各种微生物感染。
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