Experimental Trauma Surgery, Department of Trauma Surgery, University Medical Center Regensburg, Am Biopark 9, 93053 Regensburg, Germany.
Department of Trauma Surgery, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
Int J Mol Sci. 2020 Jan 28;21(3):844. doi: 10.3390/ijms21030844.
The biggest compartment of the musculoskeletal system is the tendons and ligaments. In particular, tendons are dense tissues connecting muscle to bone that are critical for the integrity, function and locomotion of this system. Due to the increasing age of our society and the overall rise in engagement in extreme and overuse sports, there is a growing prevalence of tendinopathies. Despite the recent advances in tendon research and due to difficult early diagnosis, a multitude of risk factors and vague understanding of the underlying biological mechanisms involved in the progression of tendon injuries, the toolbox of treatment strategies remains limited and non-satisfactory. This review is designed to summarize the current knowledge of triggers, trails and end state of tendinopathies.
肌肉骨骼系统中最大的部分是肌腱和韧带。特别是，肌腱是连接肌肉和骨骼的密集组织，对于该系统的完整性、功能和运动至关重要。由于我们社会的老龄化以及参与极限和过度使用运动的人数总体上升，肌腱病的发病率不断上升。尽管最近在肌腱研究方面取得了进展，但由于早期诊断困难，以及对涉及肌腱损伤进展的潜在生物学机制的多种风险因素和模糊认识，治疗策略的工具箱仍然有限且不尽如人意。本综述旨在总结肌腱病的触发因素、轨迹和终末状态的现有知识。
