西班牙输入性西尼罗河病毒 2 型感染：神经和胃肠道并发症。
Imported Human West Nile Virus Lineage 2 Infection in Spain: Neurological and Gastrointestinal Complications.
机构信息
Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain.
Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Madrid, Spain.
出版信息
Viruses. 2020 Jan 29;12(2):156. doi: 10.3390/v12020156.
We report the first human case of West Nile virus (WNV) lineage 2 infection imported to Spain by a traveler returning from Romania. Serum, cerebrospinal fluid and urine samples were analyzed and West Nile virus infection was identified by PCR and serological tests. The patient developed fever, diarrhea and neurological symptoms, accompanied by mild pancreatitis, described previously in very few cases as a complication of WNV infection and by alithiasic cholecystitis. Viral RNA was detected in urine until 30 days after the onset of symptoms and neutralizing antibodies were detected at very low titers. The phylogenetic analysis in a fragment of the NS5 gene of the virus showed a homology with sequences from WNV lineage 2 belonging to the monophyletic Central/Southern European group.
我们报告了首例由旅行者从罗马尼亚输入到西班牙的西尼罗河病毒（WNV）谱系 2 感染的人类病例。对血清、脑脊液和尿液样本进行了分析，并通过 PCR 和血清学检测确认了西尼罗河病毒感染。该患者出现发热、腹泻和神经系统症状，伴有轻度胰腺炎，这种情况以前在极少数病例中被描述为 WNV 感染的并发症，还有胆石性胆囊炎。病毒 RNA 直至症状出现后 30 天仍在尿液中检测到，并且检测到低滴度的中和抗体。对病毒 NS5 基因片段的系统发育分析显示与属于单系中/南欧组的 WNV 谱系 2 的序列具有同源性。
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