Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, Dębinki, 80-211 Gdansk, Poland.
Nutrients. 2020 Jan 29;12(2):356. doi: 10.3390/nu12020356.
Polyunsaturated fatty acids (PUFAs) are considered one of the most important components of cells that influence normal development and function of many organisms, both eukaryotes and prokaryotes. Unsaturated fatty acid desaturases play a crucial role in the synthesis of PUFAs, inserting additional unsaturated bonds into the acyl chain. The level of expression and activity of different types of desaturases determines profiles of PUFAs. It is well recognized that qualitative and quantitative changes in the PUFA profile, resulting from alterations in the expression and activity of fatty acid desaturases, are associated with many pathological conditions. Understanding of underlying mechanisms of fatty acid desaturase activity and their functional modification will facilitate the development of novel therapeutic strategies in diseases associated with qualitative and quantitative disorders of PUFA.
多不饱和脂肪酸（PUFAs）被认为是影响真核生物和原核生物正常发育和功能的细胞的最重要组成部分之一。不饱和脂肪酸去饱和酶在 PUFAs 的合成中起着至关重要的作用，它在酰基链中插入额外的不饱和键。不同类型去饱和酶的表达和活性水平决定了 PUFAs 的分布。人们已经认识到，由于脂肪酸去饱和酶的表达和活性的改变而导致的 PUFAs 分布的定性和定量变化与许多病理状况有关。了解脂肪酸去饱和酶活性的潜在机制及其功能修饰将有助于制定与 PUFAs 定性和定量紊乱相关疾病的新型治疗策略。
