Liu Kai, Liu Bo, Heilbronn Leonie K
Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia; Lifelong Health Theme, South Australia Health and Medical Research Institute Adelaide, South Australia, Australia.
Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia; Lifelong Health Theme, South Australia Health and Medical Research Institute Adelaide, South Australia, Australia.
Physiol Behav. 2020 May 1;218:112827. doi: 10.1016/j.physbeh.2020.112827. Epub 2020 Feb 1.
Obesity and overweight are contributing factors to chronic disease. Lifestyle management, which incorporates advice on moderate daily caloric restriction (CR) and physical activity to reduce body weight, is the cornerstone treatment in practice. Intermittent fasting (IF) is a popular alternative that cycles fasting with unrestricted eating periods. IF appears to be an equivalent approach to CR to induce weight loss, although as yet there is limited long-term evidence. Some controversy exists as to whether IF yields superior health benefits to CR. Discrepancies between studies may be due to the heterogeneity in the design of IF protocols. There is also still some concerns around the safety and feasibility of IF compared to CR, which has not been well-studied to date. Moreover, the underlying cellular pathways that are differentially activated in IF in comparison to CR requires further investigation in humans. This review summarises trials that have compared IF with CR, and discusses evidence from animal studies to raise questions for future research in humans.
肥胖和超重是慢性疾病的促成因素。生活方式管理是实践中的基础治疗方法，其中包括关于适度每日热量限制（CR）和体育活动以减轻体重的建议。间歇性禁食（IF）是一种流行的替代方法，它在禁食期和无限制进食期之间循环。IF似乎是一种与CR等效的诱导体重减轻的方法，尽管目前长期证据有限。关于IF是否比CR产生更好的健康益处存在一些争议。研究之间的差异可能是由于IF方案设计的异质性。与CR相比，IF的安全性和可行性也仍然存在一些担忧，迄今为止尚未对此进行充分研究。此外，与CR相比，IF中差异激活的潜在细胞途径需要在人体中进一步研究。本综述总结了比较IF与CR的试验，并讨论了来自动物研究的证据，以提出未来人体研究的问题。
