Johnson D C, Kogo H, Sen M, Dey S K
Department of Gynecology and Obstetrics, R.L. Smith Research Center, University of Kansas Medical Center, Kansas City 66103.
Toxicology. 1988 Dec 16;53(1):79-87. doi: 10.1016/0300-483x(88)90238-7.
The estrogenic action of O,P'-DDT has been known for many years. The majority of studies have used immature or ovariectomized adult rats to demonstrate estrogenic responses that require interaction with an intranuclear receptor and genic expression. However, evidence is accumulating that not all estrogenic effects are mediated by such a receptor; initiation of implantation being one such effect. The present study examined the ability of O,P'-DDT to initiate embryo implantation in the progesterone-primed uterus of a hypophysectomized adult rat. Not only did O,P'-DDT initiate implantation, it also maintained pregnancy for at least 3 days. However, when administered at the time of mating or early after fertilization, the same dosage caused loss of pre-implantation embryos. The results are consistent with the interpretation that O,P'-DDT has multiple estrogenic actions that may involve more than 1 kind of receptor.
多年来，人们一直知晓O,P'-滴滴涕的雌激素作用。大多数研究使用未成熟或去卵巢的成年大鼠来证明雌激素反应，这种反应需要与核内受体相互作用并进行基因表达。然而，越来越多的证据表明，并非所有雌激素效应都是由这种受体介导的；着床启动就是这样一种效应。本研究检测了O,P'-滴滴涕在垂体切除的成年大鼠经孕酮预处理的子宫中启动胚胎着床的能力。O,P'-滴滴涕不仅启动了着床，还维持了至少3天的妊娠。然而，在交配时或受精后早期给予相同剂量时，会导致着床前胚胎丢失。这些结果与以下解释一致，即O,P'-滴滴涕具有多种雌激素作用，可能涉及不止一种受体。
