Department of Dermatology, Saarland University, Campus Homburg, Homburg, Germany.
Institute for Medical Biometry,Epidemiology and Medical Informatics, Saarland University, Campus Homburg, Homburg, Germany.
Anticancer Res. 2020 Feb;40(2):583-595. doi: 10.21873/anticanres.13988.
BACKGROUND/AIM: Increasing evidence indicates a relevance of the vitamin D endocrine system for pathogenesis of malignant melanoma. We performed a systematic review and meta-analysis to update previous reports that investigated the association between vitamin D receptor (VDR) gene polymorphisms and melanoma risk.
A comprehensive literature search (PubMed, ISI Web of Science) identified a total of 14 studies that were eligible for inclusion in our meta-analysis. In the statistical analysis, the ORs and the 95% CIs were calculated for the dominant and recessive models for seven VDR gene polymorphisms, namely rs2228570 (FokI), rs731236 (TaqI), rs1544410 (BsmI), rs4516035 (A-1012G), rs11568820 (Cdx2), rs7975232 (ApaI) and rs739837 (BglI). Results were illustrated in Forest Plots. Publication bias was tested using Funnel Plots and the Egger's test.
Our meta-analysis showed in the dominant model (Bb + BB vs. bb) a significant association of a 15% risk reduction in malignant melanoma incidence for carriers of the rarer allele B of rs1544410 (Bsml). Notably, the dominant model (Ff + ff vs. FF) of rs2228570 (FokI) demonstrates that carriers of the rarer allele f are 22% more likely to develop malignant melanoma. For rs7975232 (ApaI), there is a 20% higher risk of melanoma for carriers of the rarer a allele (Aa + aa vs. AA). The results of the meta-analysis revealed no significant association between melanoma risk and the other investigated VDR polymorphisms.
The VDR variants FokI, ApaI and BsmI may influence the susceptibility to developing melanoma. These findings support the concept, that the vitamin D endocrine system is of importance for pathogenesis of malignant melanoma.
背景/目的：越来越多的证据表明维生素 D 内分泌系统与恶性黑色素瘤的发病机制有关。我们进行了系统评价和荟萃分析，以更新以前的研究报告，这些报告调查了维生素 D 受体 (VDR) 基因多态性与黑色素瘤风险之间的关系。
全面的文献检索（PubMed、ISI Web of Science）共确定了 14 项符合纳入荟萃分析标准的研究。在统计分析中，对于 VDR 基因的七个多态性（rs2228570 [FokI]、rs731236 [TaqI]、rs1544410 [BsmI]、rs4516035 [A-1012G]、rs11568820 [Cdx2]、rs7975232 [ApaI]和 rs739837 [BglI]），采用优势和隐性模型计算 OR 和 95%置信区间。结果以森林图表示。采用漏斗图和 Egger 检验检测发表偏倚。
我们的荟萃分析表明，在显性模型（Bb + BB 与 bb）中，rs1544410 （BsmI）中罕见等位基因 B 的携带者恶性黑色素瘤发病率降低 15%。值得注意的是，rs2228570 （FokI）的显性模型（Ff + ff 与 FF）显示，罕见等位基因 f 的携带者发生恶性黑色素瘤的可能性增加 22%。对于 rs7975232 （ApaI），罕见等位基因 a 的携带者患黑色素瘤的风险增加 20%（Aa + aa 与 AA）。荟萃分析的结果表明，VDR 多态性与黑色素瘤风险之间没有显著关联。
VDR 变体 FokI、ApaI 和 BsmI 可能影响黑色素瘤的易感性。这些发现支持了维生素 D 内分泌系统对恶性黑色素瘤发病机制重要性的概念。
