在前列腺癌中 Kisspeptin（KISS1）及其受体 GPR54（KISS1R）的表达。
Expression of Kisspeptin (KISS1) and its Receptor GPR54 (KISS1R) in Prostate Cancer.
机构信息
Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Department of Urology, General Hospital of Athens "Evaggelismos", Athens, Greece.
出版信息
Anticancer Res. 2020 Feb;40(2):709-718. doi: 10.21873/anticanres.14001.
BACKGROUND/AIM: Prostate cancer (PCa) is the second most commonly diagnosed cancer in men. In contrast to localized disease, metastatic PCa leads to increased mortality. Kisspeptin (KISS1) functions as a metastasis suppressor in various cancers. The aim of this study was to detect the expression of KISS1 and its receptor GPR54 (KISS1R) in prostate cancer.
MATERIALS AND METHODS
The expression of KISS1 and KISS1R was examined in prostate cancer tissue specimens after radical prostatectomy.
RESULTS
A higher expression of KISS1 and KISS1R was shown in patients with localized tumors (Stage ≤IIb) compared to patients with advanced (Stage ≥III) tumor. High Gleason score PCa and higher prognostic groups patients showed a lower expression rate of both KISS1 and KISS1R.
CONCLUSION
A down-regulation of KISS1-KISS1R system was detected in advanced prostate cancer. KISS1as tumor suppressor might be useful in the future for the diagnosis, risk assessment of prostate cancer progression, as well as a therapeutic target for aggressive tumors.
背景/目的：前列腺癌（PCa）是男性中第二大常见的癌症。与局限性疾病相比，转移性 PCa 导致死亡率增加。Kisspeptin（KISS1）在各种癌症中作为转移抑制因子发挥作用。本研究旨在检测前列腺癌中 KISS1 及其受体 GPR54（KISS1R）的表达。
材料和方法
在根治性前列腺切除术后，检测前列腺癌组织标本中 KISS1 和 KISS1R 的表达。
结果
与晚期（≥III 期）肿瘤患者相比，局限性肿瘤（≤IIb 期）患者的 KISS1 和 KISS1R 表达更高。高 Gleason 评分 PCa 和更高预后组患者的 KISS1 和 KISS1R 表达率较低。
结论
在晚期前列腺癌中检测到 KISS1-KISS1R 系统下调。KISS1 作为肿瘤抑制因子，将来可能对前列腺癌进展的诊断、风险评估以及侵袭性肿瘤的治疗靶点有用。
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