Kostakis Ioannis D, Agrogiannis George, Vaiopoulos Aristeidis G, Mylona Eleni, Patsouris Efstratios, Kouraklis Gregory, Koutsilieris Michael
Second Department of Propedeutic Surgery, "Laiko" General Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
J BUON. 2018 Jan-Feb;23(1):79-84.
Kisspeptins, which are derived from the gene KISS1, supress tumor progression. We intended to investigate the production of KISS1 and its receptor (KISSR) in gastric cancer.
The expression of KISS1 and KISS1R in both normal and cancer tissue was examined with immunohistochemistry in tissue specimens of 40 cases of gastric adenocarcinoma.
KISS1 expression in normal gastric mucosa was much higher than in malignant mucosa. KISS1 expression was higher in early stages (stage I or II) than in advanced stages (stage III or IV), in tumors with intestinal histological type than in those with diffuse histological type, in tumors without lymphovascular invasion than in those with and in cancers of older patients (≥70 years) than in younger patients. No significant differences were found regarding other clinicopathological parameters. There was no KISS1R expression in cancer tissues, while only low levels of KISS1R were detected in normal gastric epithelium.
KISS1 expression is decreased during carcinogenesis in gastric mucosa. More advanced tumors and more aggressive histological types produce lower KISS1 levels. In addition, no KISS1R is produced in malignant gastric epithelium, while KISS1R is only weakly expressed in normal gastric epithelium.
源自KISS1基因的 kisspeptins可抑制肿瘤进展。我们旨在研究KISS1及其受体（KISSR）在胃癌中的产生情况。
采用免疫组织化学法检测40例胃腺癌组织标本中正常组织和癌组织中KISS1和KISS1R的表达。
KISS1在正常胃黏膜中的表达远高于恶性黏膜。KISS1在早期（I期或II期）肿瘤中的表达高于晚期（III期或IV期），在肠型组织学类型的肿瘤中高于弥漫型组织学类型的肿瘤，在无淋巴管浸润的肿瘤中高于有淋巴管浸润的肿瘤，在老年患者（≥70岁）的癌症中高于年轻患者。在其他临床病理参数方面未发现显著差异。癌组织中未检测到KISS1R表达，而在正常胃上皮中仅检测到低水平的KISS1R。
胃黏膜癌变过程中KISS1表达降低。更晚期的肿瘤和侵袭性更强的组织学类型产生的KISS1水平更低。此外，恶性胃上皮中不产生KISS1R，而KISS1R在正常胃上皮中仅弱表达。
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