KISS1和KISS1R在原发性和转移性结直肠癌中的表达。
KISS1 and KISS1R expression in primary and metastatic colorectal cancer.
作者信息
Matthaiou Spyridon, Kostakis Ioannis D, Kykalos Stylianos, Machairas Nikolaos, Spartalis Eleftherios, Ntikoudi Evangelia, Lambropoulou Maria, Karayiannakis Anastasios, Machairas Nikolaos
机构信息
Second Department of Surgery, Alexandroupolis University Hospital, Democritus University of Thrace, Medical School, Alexandroupolis, Greece.
出版信息
J BUON. 2018 May-Jun;23(3):598-603.
PURPOSE
Kisspeptins are produced by the KISS1 gene and have tumor-suppressing and anti-metastatic properties. Our aim was to study the expression of KISS1 and its receptor, KISS1R, in colorectal cancer.
METHODS
KISS1 and KISS1R expression was detected using immunohistochemistry in malignant tissue samples from 66 patients (34 men, 32 women) with colorectal adenocarcinoma. In total, 74 tumor samples were studied, 57 samples from primary tumors and 17 samples from liver metastases. KISS1 and KISS1R levels were associated with various clinicopathological parameters and survival data.
RESULTS
KISS1 expression was higher in primary tumors with advanced stage (III or IV) and in those with infiltrated lymph nodes. KISS1R expression was higher in primary tumors with distant metastases. No significant differences were detected between primary and metastatic tumors regarding KISS1 and KISS1R levels. Furthermore, patients with high KISS1R levels had longer overall survival.
CONCLUSIONS
KISS1 and KISS1R expression is higher in advanced colorectal cancers and high KISS1R levels are associated with better prognosis in colorectal cancer.
目的
亲吻素由KISS1基因产生，具有肿瘤抑制和抗转移特性。我们的目的是研究KISS1及其受体KISS1R在结直肠癌中的表达。
方法
采用免疫组织化学法检测66例（34例男性，32例女性）结直肠腺癌患者恶性组织样本中KISS1和KISS1R的表达。共研究了74个肿瘤样本，其中57个来自原发性肿瘤，17个来自肝转移灶。KISS1和KISS1R水平与各种临床病理参数及生存数据相关。
结果
KISS1在晚期（III期或IV期）原发性肿瘤及有淋巴结浸润的肿瘤中表达较高。KISS1R在有远处转移的原发性肿瘤中表达较高。原发性肿瘤和转移瘤在KISS1和KISS1R水平上未检测到显著差异。此外，KISS1R水平高的患者总生存期更长。
结论
晚期结直肠癌中KISS1和KISS1R表达较高，且KISS1R水平高与结直肠癌较好的预后相关。
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