碱化治疗对转移性或复发性胰腺癌化疗结果的影响。
Effects of Alkalization Therapy on Chemotherapy Outcomes in Metastatic or Recurrent Pancreatic Cancer.
机构信息
Japanese Society on Inflammation and Metabolism in Cancer, Kyoto, Japan
Japanese Society on Inflammation and Metabolism in Cancer, Kyoto, Japan.
出版信息
Anticancer Res. 2020 Feb;40(2):873-880. doi: 10.21873/anticanres.14020.
BACKGROUND/AIM: The acidic tumor microenvironment is associated both with the progression and drug resistance of cancer. We aimed to investigate the effects of alkalization therapy performed concurrently with chemotherapy on the survival of advanced pancreatic cancer patients (study registration: UMIN 000035659).
PATIENTS AND METHODS
Twenty-eight patients with metastatic or recurrent pancreatic cancer were assessed in this study. Alkalization therapy consisted of an alkaline diet with supplementary oral sodium bicarbonate (3.0-5.0 g/day).
RESULTS
The mean urine pH was significantly higher after the alkalization therapy (6.85±0.74 vs. 6.39±0.92; p<0.05). The median overall survival from the start of alkalization therapy of the patients with high urine pH (>7.0) was significantly longer than those with low urine pH (≤ 7.0) (16.1 vs. 4.7 months; p<0.05).
CONCLUSION
An alkalization therapy may be associated with better outcomes in advanced pancreatic cancer patients treated with chemotherapy.
背景/目的：酸性肿瘤微环境与癌症的进展和耐药性都有关。我们旨在研究同时进行碱化治疗与化疗对晚期胰腺癌患者生存的影响（研究注册：UMIN 000035659）。
患者和方法
本研究评估了 28 例转移性或复发性胰腺癌患者。碱化治疗包括碱性饮食和口服补充碳酸氢钠（3.0-5.0 g/天）。
结果
碱化治疗后尿液 pH 值显著升高（6.85±0.74 比 6.39±0.92；p<0.05）。尿液 pH 值较高（>7.0）的患者从开始碱化治疗到总体生存的中位数明显长于尿液 pH 值较低（≤7.0）的患者（16.1 比 4.7 个月；p<0.05）。
结论
在接受化疗的晚期胰腺癌患者中，碱化治疗可能与更好的结果相关。
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