Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, U.S.A.
Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, U.S.A.
Anticancer Res. 2020 Feb;40(2):951-955. doi: 10.21873/anticanres.14028.
Ewing sarcoma (ES) is an undifferentiated small round blue cell tumor most commonly originating in the bone of adolescents 10-20 years of age, although 30% are diagnosed in adults. The most important prognostic factor is the presence of metastatic disease. Results of the EURO-EWING 99 trial of ES patients showed that local treatment of not only the primary, but also of the sites of metastatic disease should be considered to improve event-free survival. The use of stereotactic body radiotherapy (SBRT) has been extensively reported for tumors of lung, liver, pancreas, and spine. The use of SBRT in these sites is well-accepted. Here, we report a detailed case of SBRT to multisite metastatic ES. We demonstrate the feasibility, safety, and efficacy of aggressive local control with multisite SBRT for the treatment of metastatic ES.
尤因肉瘤（ES）是一种未分化的小圆细胞蓝色肿瘤，最常见于 10-20 岁青少年的骨中，尽管 30%的病例发生在成年人中。最重要的预后因素是存在转移性疾病。ES 患者的 EURO-EWING 99 试验结果表明，不仅应考虑对原发性肿瘤，还应考虑对转移部位进行局部治疗，以改善无事件生存。立体定向体放射治疗（SBRT）已广泛用于治疗肺、肝、胰腺和脊柱肿瘤。SBRT 在这些部位的应用已被广泛接受。在这里，我们报告了一例多部位转移性 ES 的 SBRT 详细病例。我们证明了多部位 SBRT 进行积极的局部控制治疗转移性 ES 的可行性、安全性和疗效。
