Guo Wen-Qin, Chen Ying-Ge, Shi Rong-Zhen, He Kai, Wang Jian-Feng, Shao Jin-Hui, Wan Jian-Bo, Gao Jian-Li
Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou, Zhejiang 310009, China.
Evid Based Complement Alternat Med. 2020 Jan 3;2020:8747023. doi: 10.1155/2020/8747023. eCollection 2020.
(PN) has been used as a - and blood-activating () drug for thousands of years in China. It has also been widely used as an anticancer drug at present. As a drug, the effect of PN on hematopoietic differentiation in tumor-bearing body has been paid more and more attention. Our research found that panax notoginseng saponins (PNS), especially panaxadiol saponins (PDS) and its aglucon (PPD), could improve the immunosuppressive state by regulating the abnormal hematopoietic differentiation in a tumor-bearing body by multiple ways. An interesting phenomenon is that PDS reduced the neutrophil-lymphocyte ratio (NLR) via its inhibition effect on the granule-monocyte differentiation of spleen cells, which is associated with a decrease in the secretion of tumor MPO, G-CSF, PU.1, and C/EBP. Otherwise, PDS increased the proportion of both hematopoietic stem cells and erythroid progenitor cells in the bone marrow, but inhibited spleen erythroid differentiation via inhibiting secretion of tumor EPO, GATA-1, and GATA-2. This study suggests that PNS regulated the tumor-induced abnormal granule-monocyte differentiation of hematopoietic stem cells, affecting the distribution and function of haemocytes in tumor-bearing mice.
三七在中国作为活血化瘀药已使用了数千年。目前它也被广泛用作抗癌药物。作为一种药物，三七对荷瘤机体造血分化的影响越来越受到关注。我们的研究发现，三七总皂苷（PNS），尤其是三七二醇皂苷（PDS）及其苷元（PPD），可通过多种方式调节荷瘤机体异常的造血分化来改善免疫抑制状态。一个有趣的现象是，PDS通过对脾细胞颗粒 - 单核细胞分化的抑制作用降低了中性粒细胞与淋巴细胞比值（NLR），这与肿瘤髓过氧化物酶（MPO）、粒细胞集落刺激因子（G - CSF）、PU.1和C/EBPβ分泌减少有关。此外，PDS增加了骨髓中造血干细胞和红系祖细胞的比例，但通过抑制肿瘤促红细胞生成素（EPO）、GATA - 1和GATA - 2的分泌抑制脾脏红系分化。本研究表明，PNS调节肿瘤诱导的造血干细胞异常颗粒 - 单核细胞分化，影响荷瘤小鼠血细胞的分布和功能。
